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Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted to substance C by enzymes 1 and 2. Substance B is the intermediate produced in this pathway: a. If an individual is homozygous for a null mutation in the gene that codes for enzyme 1, what will the result be? b. If an individual is homozygous for a null mutation in enzyme 2, what will the result be? c. What if an individual is heterozygous for a dominant mutation in which enzyme 1 is overactive? d. What if an individual is heterozygous for a mutation that abolishes the activity of enzyme 2 (a null mutation)?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 10, Problem 4QP
Textbook Problem
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Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted to substance C by enzymes 1 and 2. Substance B is the intermediate produced in this pathway:

Chapter 10, Problem 4QP, Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted

a. If an individual is homozygous for a null mutation in the gene that codes for enzyme 1, what will the result be?

b. If an individual is homozygous for a null mutation in enzyme 2, what will the result be?

c. What if an individual is heterozygous for a dominant mutation in which enzyme 1 is overactive?

d. What if an individual is heterozygous for a mutation that abolishes the activity of enzyme 2 (a null mutation)?

a.

Summary Introduction

To explain: The results if the person is homozygous for a null mutation in the gene that codes for enzyme 1 for the given metabolic pathway.

Introduction: Metabolic pathways are catalyzed by using enzymes. These enzymes are synthesized based on the information provided by the genes specified for them. Any change in these genes can hinder the synthesis of these enzymes or may lead to the synthesis of faulty enzymes. Null mutation makes the enzymes non-functional or makes them non-existent.

Explanation of Solution

Enzyme 1 will not synthesize or be non-functional in the person having the homozygous genotype of the full mutation. This faulty enzyme 1 will not convert substance A into B...

b.

Summary Introduction

To explain: The results if the person is homozygous for a null mutation in enzyme 2 for the given metabolic pathway.

Introduction: Metabolic pathways are catalyzed by using enzymes. These enzymes are synthesized based on the information provided by the genes specified for them. Any change in these genes can hinder the synthesis of these enzymes or may lead to the synthesis of faulty enzymes. Null mutation makes the enzymes non-functional or makes them non-existent.

c.

Summary Introduction

To explain: The possible results if an individual is heterozygous for a dominant mutation in which enzyme 1 becomes overactive.

Introduction: Metabolic pathways are catalyzed by using enzymes. These enzymes are synthesized based on the information provided by the genes specified for them. Any change in these genes can hinder the synthesis of these enzymes or may lead to the synthesis of faulty enzymes. Null mutation makes the enzymes non-functional or makes them non-existent.

d.

Summary Introduction

To explain: The possible results if an individual is heterozygous for a null mutation of enzyme 2.

Introduction: Metabolic pathways are catalyzed by using enzymes. These enzymes are synthesized based on the information provided by the genes specified for them. Any change in these genes can hinder the synthesis of these enzymes or may lead to the synthesis of faulty enzymes. Null mutation makes the enzymes non-functional or makes them non-existent.

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