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Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 12, Problem 29P
Fred and Mary have a child named Bob. The genomic DNAs of these three individuals are used as probes to ASO microarrays such as that shown in Fig. 10.17 on p. 356. The results with 10 SNP loci (1–10) located along chromosome 21 are shown in the figure that follows. Yellow, orange, and red indicate increasing intensities of hybridization.
a. | Is Bob likely to have Down syndrome? Explain. |
b. | Do the data provide evidence that a nondisjunction event occurred in one of the parents? If so, in which parent and during which meiotic division? |
c. | Do the data provide evidence that a recombination event occurred during meiosis in either parent? If so, in which parent, and describe the approximate location of the recombination event. |
d. | Describe how this example illustrates why it is important when tracking nondisjunction events to look particularly at loci near the centromere. |
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Students have asked these similar questions
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Chapter 12 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 12 - For each of the terms in the left column, choose...Ch. 12 - Prob. 2PCh. 12 - For each of the following types of chromosomal...Ch. 12 - For the following types of chromosomal...Ch. 12 - One of the X chromosomes in a particular...Ch. 12 - Prob. 6PCh. 12 - Prob. 7PCh. 12 - Prob. 8PCh. 12 - Two wild-type fragments of human genomic DNA from...Ch. 12 - Indicate which of the four major classes of...
Ch. 12 - The recessive, X-linked z1 mutation of the...Ch. 12 - Genes a and b are 21 m.u. apart when mapped in...Ch. 12 - In the following group of figures, the pink lines...Ch. 12 - Three strains of Drosophila Bravo, X-ray, and...Ch. 12 - Prob. 15PCh. 12 - Suppose a haploid yeast strain carrying two...Ch. 12 - In the mating between two haploid yeast strains...Ch. 12 - During ascus formation in Neurospora, any...Ch. 12 - In the following figure, black and pink lines...Ch. 12 - In Drosophila, the gene for cinnabar eye color is...Ch. 12 - Semisterility in corn, as seen by unfilled ears...Ch. 12 - Prob. 22PCh. 12 - Prob. 23PCh. 12 - Prob. 24PCh. 12 - Duchenne muscular dystrophy DMD is caused by a...Ch. 12 - Explain how transposable elements can cause the...Ch. 12 - The Drosophila genome normally harbors about 40 P...Ch. 12 - Prob. 28PCh. 12 - Fred and Mary have a child named Bob. The genomic...Ch. 12 - Uniparental disomy is a rare phenomenon in which...Ch. 12 - Among adults with Turner syndrome, it has been...Ch. 12 - In Neurospora, his2 mutants require the amino acid...Ch. 12 - Human geneticists interested in the effects of...Ch. 12 - The incidence of Down syndrome will be very high...Ch. 12 - The Drosophila chromosome 4 is extremely small;...Ch. 12 - Down syndrome is usually caused by having a...Ch. 12 - Common red clover, Trifolium pratense, is a...Ch. 12 - The numbers of chromosomes in the somatic cells of...Ch. 12 - Prob. 39PCh. 12 - Somatic cells in organisms of a particular diploid...Ch. 12 - Prob. 41PCh. 12 - Prob. 42PCh. 12 - Chromosomes normally associate during meiosis I as...Ch. 12 - Using whole-genome sequencing, how could you...Ch. 12 - Prob. 45PCh. 12 - Prob. 46PCh. 12 - Seedless watermelons that you find in the...Ch. 12 - Prob. 48PCh. 12 - What characteristic property of translocations...Ch. 12 - In examining the genome of the rice Oryza sativa...Ch. 12 - Prob. 51PCh. 12 - Prob. 52PCh. 12 - The accompanying figure shows idiograms of human...
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