Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 12, Problem 2P
Summary Introduction

a.

To determine:

The appearance of chromosome 1 after FISH having genotypes Del1/Del2.

Introduction:

Human chromosome 1 is a large metacentric chromosome. Some of the telomeric regions on the chromosome were barcoded by multicolor banding. Fluorescence In situ Hybridization technique (FISH) is used to label the DNA probes.

Summary Introduction

b.

To determine:

The appearance of chromosome 1 after FISH having genotypes Del1/+.

Introduction:

Multicolor banding is done towards the telomeric end of chromosome 1 using different fluorescent dyes. This technique of banding is called FISH. The banding pattern is unique for different genotypes.

Summary Introduction

c.

To determine:

The appearance of chromosome 1 after FISH having genotypes Inv1/+.

Introduction:

Inversion refers to a type of chromosomal mutation in which a segment of a chromosome gets reversed from one end to the other. Inversion is of two types, paracentric and pericentric inversion. Pericentric inversion includes the centromere, whereas; paracentric inversion does not involve centromere.

Summary Introduction

d.

To determine:

The appearance of chromosome 1 after FISH having genotypes Inv2/+.

Introduction:

Inversion can be classified into two types, paracentric and pericentric inversion. Pericentric inversion includes the centromere, whereas; paracentric inversion does not involve centromere.

Summary Introduction

e.

To determine:

The appearance of chromosome 1 after FISH having genotypes Inv2/Inv2.

Introduction:

The technique of banding the chromosomal region by using different fluorescent dyes is called FISH. The banding pattern is unique for different genotypes.

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Chapter 12 Solutions

Genetics: From Genes to Genomes, 5th edition

Ch. 12 - The recessive, X-linked z1 mutation of the...Ch. 12 - Genes a and b are 21 m.u. apart when mapped in...Ch. 12 - In the following group of figures, the pink lines...Ch. 12 - Three strains of Drosophila Bravo, X-ray, and...Ch. 12 - Prob. 15PCh. 12 - Suppose a haploid yeast strain carrying two...Ch. 12 - In the mating between two haploid yeast strains...Ch. 12 - During ascus formation in Neurospora, any...Ch. 12 - In the following figure, black and pink lines...Ch. 12 - In Drosophila, the gene for cinnabar eye color is...Ch. 12 - Semisterility in corn, as seen by unfilled ears...Ch. 12 - Prob. 22PCh. 12 - Prob. 23PCh. 12 - Prob. 24PCh. 12 - Duchenne muscular dystrophy DMD is caused by a...Ch. 12 - Explain how transposable elements can cause the...Ch. 12 - The Drosophila genome normally harbors about 40 P...Ch. 12 - Prob. 28PCh. 12 - Fred and Mary have a child named Bob. The genomic...Ch. 12 - Uniparental disomy is a rare phenomenon in which...Ch. 12 - Among adults with Turner syndrome, it has been...Ch. 12 - In Neurospora, his2 mutants require the amino acid...Ch. 12 - Human geneticists interested in the effects of...Ch. 12 - The incidence of Down syndrome will be very high...Ch. 12 - The Drosophila chromosome 4 is extremely small;...Ch. 12 - Down syndrome is usually caused by having a...Ch. 12 - Common red clover, Trifolium pratense, is a...Ch. 12 - The numbers of chromosomes in the somatic cells of...Ch. 12 - Prob. 39PCh. 12 - Somatic cells in organisms of a particular diploid...Ch. 12 - Prob. 41PCh. 12 - Prob. 42PCh. 12 - Chromosomes normally associate during meiosis I as...Ch. 12 - Using whole-genome sequencing, how could you...Ch. 12 - Prob. 45PCh. 12 - Prob. 46PCh. 12 - Seedless watermelons that you find in the...Ch. 12 - Prob. 48PCh. 12 - What characteristic property of translocations...Ch. 12 - In examining the genome of the rice Oryza sativa...Ch. 12 - Prob. 51PCh. 12 - Prob. 52PCh. 12 - The accompanying figure shows idiograms of human...
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