Concept explainers
To analyze:
The time taken by the DNA polymerase to complete the replication process of the entire DNA molecule of the shortest chromosome, by moving uninterruptedly from one end to the other end. Also figure out whether
Given:
The DNA polymerase proceeds uninterruptedly on the DNA strand, from one end to the other end to synthesize the new DNA strand. Addition of
Introduction:
The division of cells in a cell cycle involves two phases: interphase and mitotic phase. Replication of the genetic material takes place during synthesis phase or S phase of the interphase. DNA polymerase is responsible for DNA replication in both eukaryotes and prokaryotes.
Explanation of Solution
The rate at which DNA polymerase proceeds the formation of new DNA strand is 50 bp/s. Therefore, to replicate a DNA strand of
The synthesis phase of a mammalian cell is 8 hours long, and the entire replication process occurs during this time. This indicates that there must be multiple DNA polymerase complexes involved in this process. Hence more than one replication origin sites must be there, where the enzyme would attach itself to synthesize a new strand.
Therefore, it can be concluded that there are many replication origin sites where DNA polymerase enzyme work simultaneously, to complete the synthesis of new DNA strand.
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Chapter 13 Solutions
EBK LIFE: THE SCIENCE OF BIOLOGY
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- Give only typing answer with explanation and conclusion You are studying a strain of bacteria that carries a temperature-sensitive mutation in one of the genes required for DNA replication. The bacteria grow normally at the lower temperature, but when the temperature is raised they die. When you analyze the remains of the bacterial cells grown at the higher temperature you find evidence of partly replicated DNA. When the strands of this DNA are separated by heating, numerous single-stranded DNA molecules around 1000 nucleotides long are found. Which of the proteins listed below are most likely to be impaired in these mutant bacteria and why?: Primase, Helicase, or DNA Polymerase?arrow_forward(e) What difference would it make to bidirectional DNA replication if both modes of chain extension were equally favourable?arrow_forwardAnswer the following questions with regards to DNA replication:1. In what direction does DNA polymerase read the parent strand?2. Describe why Okazaki fragments are formed (1-2 sentences)3. In no more than one sentence describe the function of the following enzymes as it pertains to DNA replication in E. coli : DNA polymerase III, primase and ligasearrow_forward
- Assume that a certain bacterial chromosome has one origin of replication. Under some conditions of rapid cell division, replication could start from the origin before the preceding replication cycle is complete. How many replication forks would be present under these conditions?arrow_forwardExplain the complexities of DNA replication that make the process (a) bidirectional and (b) continuous in one strand and discontinuous in the other.arrow_forwardOne strand of a single DNA helix is labeled red while the other strand of the same DNA helix is labeled blue. This double helix DNA is replicated through the process of semi-conservative replication. Note that a completely newly synthesized strand of DNA will be white. After three rounds of DNA replication, how many all-white DNA (both strands are white) will there be? Explain your reasoning.arrow_forward
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