Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 14, Problem 26PIAT
Summary Introduction
To analyze:
The probability of the first child of the couple to have ALD (adrenoleukodystrophy).
Introduction:
Adrenoleukodystrophy is a type of X-linked disorder. It occurs as a result of mutation in the ABCD1 gene, which is present on the Xq28 chromosome. Furthermore, the nonfunctioning of these enzymes damages the myelin sheath present on the axon, which further causes degeneration of the neuron. In the given pedigree, the first daughter in the last generation is married to a man with no history of ALD in his family. Being a genetic counselor, advise the couple about chances of their first child having ALD. The pedigree is shown below:
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Chapter 14 Solutions
Biological Science (6th Edition)
Ch. 14 - 1. The genes for the trails that Mendel worked...Ch. 14 - 2. CAUTION Why is the pea wrinkled-seed allele a...Ch. 14 - Prob. 3TYKCh. 14 - 4. Mendel’s rules do not correctly predict...Ch. 14 - Prob. 5TYKCh. 14 - Prob. 6TYKCh. 14 - Example Problem Two black female mice are crossed...Ch. 14 - Prob. 8TYKCh. 14 - Prob. 9TYPSSCh. 14 - Prob. 10TYPSS
Ch. 14 - 11. In garden peas, yellow seeds (Y) are dominant...Ch. 14 - Prob. 12TYPSSCh. 14 - The smooth feathers on the back of the neck in...Ch. 14 - SOCIETY As a genetic counselor, you advise couples...Ch. 14 - 15. Suppose you are heterozygous for two genes...Ch. 14 - Suppose a woman with blood type O married a man...Ch. 14 - Prob. 17TYPSSCh. 14 - Society Two mothers give birth to sons at the same...Ch. 14 - Prob. 19TYPSSCh. 14 - QUANTITATIVE Recall that hemophilia is an X-linked...Ch. 14 - Prob. 21PIATCh. 14 - Given the pedigree, what is the most likely mode...Ch. 14 - Prob. 23PIATCh. 14 - QUANTITATIVE If the son with ALD in the third...Ch. 14 - Prob. 25PIATCh. 14 - Prob. 26PIAT
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? 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