The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

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Chapter 15, Problem 13QP

Summary Introduction

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

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Shown below is a double-stranded bacterial (E. coli) DNA sequence coding for a hypothetical protein. The nucleotides are numbered 1 to 100. a)Although the transcription start site begins at the underlined C/G, which of the following is the nucleotide sequences needed upstream for transcription to actually occur? b)What are the first 15 nucleotides of the mRNA? c)What are the first 5 amino acids translated from the resulting mRNA? d)A different mutation results in the substitution of the T/A base pair at position 30 (shown in bold and underlined) with a G/C base pair. How would this mutation affect the sequence of the protein that is produced?

Consider the following mRNA base sequence 5' CUG-CAC 3' (a) What dipeptide is coded for by this mRNA? (b) What dipeptide is formed if a mutation converts CUG to CUU? (c) What dipeptide is formed if a mutation converts CAC to CGC? (d) What dipeptide is formed if a mutation converts CUG to CUU and CAC to CGC?

Refer to the DNA sequence provided: 3’ -TACTGAAGCGGCAGCCCCGCATGAGTAGACCTTACT-5’ a. What is the mRNA transcript of the anticoding strand of the DNA model? b. What is the amino acid sequence of the polypeptide chain that will be translated from the mRNA in (a)?

Answer 2

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Chapter 15, Problem 13QP

Summary Introduction

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

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Answer 3

Question

Chapter 15, Problem 13QP

Summary Introduction

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

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Answer 4

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Chapter 15, Problem 13QP

Summary Introduction

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

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Answer 5

Chapter 15, Problem 13QP

Summary Introduction

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

Answer 6

Chapter 15, Problem 13QP

Summary Introduction

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

Answer 7

Chapter 15, Problem 13QP

Summary Introduction

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

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Answer 11

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The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

Solution Summary: The author explains that the CFTR gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein.

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

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