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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 15, Problem 13QP
Textbook Problem
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Sequence comparison studies revealed that the product of the CFTR (cystic fibrosis) gene has a strong similarity to proteins known to be involved in:

  1. a. transcription
  2. b. translation
  3. c. transport of ions across the cell membrane
  4. d. mRNA splicing
  5. e. movement of proteins across the Golgi membrane

Summary Introduction

Introduction: The CFTR (cystic fibrosis) gene is responsible for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein works as a channel across the cell membrane and regulates the transportation of the chloride ions in the cells of an organism.

Explanation of Solution

Reason for correct answer:

The CFTR gene was isolated by positional cloning and mapped to chromosome 7. This gene was mapped to the long arm of chromosome 7. The positional cloning of the CFTR gene is useful in understanding the genetic defects related to the cystic fibrosis disease

Option c. is given as “transport of ions across the cell membrane.”

The protein comparison revealed that the amino acid sequence of the CFTR gene is similar to the amino acid sequence of membrane proteins that regulate the transportation of ions across the cell membrane. The patients, who are suffering from cystic fibrosis, have problems with chloride ion flow and the membrane proteins which are responsible for the transportation of ions across the cell membrane. Hence, the correct answer is option c.

Reasons for the incorrect answer:

Option a. is given as, “transcription.”

The amino acid sequence of the CFTR gene was developed by its positional cloning and mapping to chromosome 7. The amino acid sequence of the CFTR gene resembles the amino acid sequence of the transmembrane protein...

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