Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 15.3, Problem 1COMQ
How can methylation affect transcription?
a. It may prevent the binding of regulatory transcription factors.
b. It may enhance the binding of regulatory transcription factors.
c. It may attract methyl-CpG-binding proteins, which inhibit transcription, to bind to a methylated sequence.
d. All of the above are possible ways for methylation to affect transcription
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How can methylation affect transcription?
a. It may prevent the binding of regulatory transcription factors.
b. It may enhance the binding of regulatory transcription factors.
c. It may attract methyl-CpG-binding proteins, which inhibit transcription, to bind to a methylated sequence.
d. All of the above are possible ways for methylation to affect transcription
Can one transcription factor sometimes act as a repressor and sometimes act as an activator?
a. Yes, but it depends on where the transcription factor binds in the promoter
b. Yes, but it depends on other proteins that might act with the transcription factor
c. No, transcription factors are always either activators or repressors
d. Yes, but only if a mutation happens
How can methylation affect transcription?a. It may prevent the binding of regulatory transcription factors.b. It may enhance the binding of regulatory transcription factors.c. It may promote the binding of methyl-CpG-binding proteins,which inhibit transcription.d. All of the above are possible ways for methylation to affecttranscription.
Chapter 15 Solutions
Genetics: Analysis and Principles
Ch. 15.1 - 1. Combinatorial control refers to the phenomenon...Ch. 15.1 - 2. A regulatory transcription factor protein...Ch. 15.1 - 3. A bidirectional enhancer has the following...Ch. 15.1 - 4. Regulatory transcription factors can be...Ch. 15.2 - 1. A chromatin-remodeling complex may
a. change...Ch. 15.2 - Prob. 2COMQCh. 15.2 - 3. Which of the following characteristics is...Ch. 15.2 - 4. Transcriptional activation of eukaryotic genes...Ch. 15.3 - How can methylation affect transcription? a. It...Ch. 15.3 - 2. The process in which completely unmethylated...
Ch. 15.4 - Prob. 1COMQCh. 15.5 - The overall goal of the ENCODE Project is a. to...Ch. 15.6 - The binding of iron regulatory protein (IRP) to...Ch. 15 - Discuss the common points of control in eukaryotic...Ch. 15 - 2. Discuss the structure and function of...Ch. 15 - 3. What is meant by the term transcription factor...Ch. 15 - What are the functions of transcriptional...Ch. 15 - 5. Is each of the following statements true or...Ch. 15 - 6. Transcription factors usually contain one or...Ch. 15 - Prob. 7CONQCh. 15 - Prob. 8CONQCh. 15 - 9. Let’s suppose a mutation in the glucocorticoid...Ch. 15 - Prob. 10CONQCh. 15 - Prob. 11CONQCh. 15 - Prob. 12CONQCh. 15 - 13. Transcription factors such as the...Ch. 15 - An enhancer, located upstream from a gene, has the...Ch. 15 - 15. The DNA-binding domain of each CREB protein...Ch. 15 - The gene that encodes the enzyme called tyrosine...Ch. 15 - Prob. 17CONQCh. 15 - 18. What is a histone variant?
Ch. 15 - Prob. 19CONQCh. 15 - 20. What is meant by the term histone code? With...Ch. 15 - Prob. 21CONQCh. 15 - Histones are thought to be displaced as RNA...Ch. 15 - 23. What is an insulator? Describe two different...Ch. 15 - 24. What is DNA methylation? When we say that DNA...Ch. 15 - Lets suppose that a vertebrate organism carries a...Ch. 15 - 26. What is a CpG island? Where would you expect...Ch. 15 - Describe how the binding of iron regulatory...Ch. 15 - 1. Briefly describe the method of chromatin...Ch. 15 - Researchers can isolate a sample of cells, such as...Ch. 15 - Prob. 3EQCh. 15 - Prob. 4EQCh. 15 - Prob. 5EQCh. 15 - 6. As described in Chapter 21, an electrophoretic...Ch. 15 - Prob. 7EQCh. 15 - 1. Explain how DNA methylation could be used to...Ch. 15 - 2. Enhancers can occur almost anywhere in DNA and...
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- Why is regulating transcription the main way that cells control gene expression? A. Because transcription is the last step in gene expression, stopping here ensures that the cell has a stockpile of proteins to prepare them from all unexpected environmental changes. B. Because transcription involves interactions with DNA, preventing transcription reduces the changes of mutation in the cell’s genome. C. Because transcription is the first step in gene expression, stopping at transcription reduces the amount of energy and resources used by producing unnecessary gene products. D. Because transcription is the shortest step in gene expression, preventing transcription has little effect on the rate of protein production.arrow_forwardIf a mutation occurred in a control element sequence associated with a particular gene, which of the following would be a likely consequence of this? A. This mutation is not likely to affect the expression of the associated gene, because RNA polymerase does not bind to control elements. B. This will likely affect the expression of the associated gene because it will loosen the coiling of chromatin at this site. C. The expression of the associated gene will be affected because this change will result in a nonsense mutation. D. This mutation is not likely to affect the expression of the associated gene, since control elements are noncoding sequences. E. The associated gene's expression would likely be affected, since this mutation would change the ability of at least one transcription factor to bind.arrow_forwardWhich of the following is true of CpG islands? a. They are methylated near promoters of actively transcribed genes. b. They are unmethylated near promoters of actively transcribed genes. c. Acetylation of CpG islands leads to repression of transcription. d. CpG islands code for RNA molecules that activate transcription.arrow_forward
- What is the difference between the core promoter and the regulatory promoter? a. Only the core promoter has consensus sequences. b. The regulatory promoter is farther upstream of the gene. c. General transcription factors bind to the core promoter; transcriptional activator proteins bind to the regulatory promoter. d. Both b and c.arrow_forwardMutations that occur at the end of a gene may alter the sequence of the gene and prevent transcriptional termination. A. What types of mutations would prevent ρ-independent termination? B. What types of mutations would prevent ρ-dependent termination? C. If a mutation prevented transcriptional termination at the end of a gene, where would gene transcription end? Or would it end?arrow_forwardWhich of the following mutations could be appropriately describedas a position effect?A. A point mutation at the –10 position in the promoter regionprevents transcription. B. A translocation places the coding sequence for a muscle-specificgene next to an enhancer that is turned on in nerve cells.C. An inversion flips a gene from the long arm of chromosome 17(which is euchromatic) to the short arm (which isheterochromatic).arrow_forward
- Specific transcription factors in eukaryotes interact with enhancers, which may be a long distance from the promoter. These transcription factors then a. alter the structure of the DNA between enhancer and promoter. b. do not interact with the transcription apparatus. c. can interact with the transcription apparatus via DNA looping. d. can interact with the transcription apparatus by removing the intervening DNA.arrow_forward(a) Did deletion of any of the possible control elements cause areduction in reporter gene expression? If so, which one(s), and howcan you tell? (b) If loss of a control element causes a reduction ingene expression, what must be the normal role of that controlelement? Provide a biological explanation for how the loss of sucha control element could lead to a reduction in gene expression.arrow_forwardIs each of the following statements true or false? A. An enhancer is a type of regulatory element. B. A core promoter is a type of regulatory element. C. Regulatory transcription factors bind to regulatory elements. D. An enhancer may cause the down regulation of transcription.arrow_forward
- What determines which transcription factors will be able to regulate a particular gene's expression? A. The collection of control element sequences that are associated with that gene B. The location of that gene sequence (which chromosome it is located on) C. The sequence of introns present in that gene D. The sequence of exons present in that gene ..arrow_forwardWhich of the following is true of transcription factors? A)The same transcription factors are found in all cell types. B)They can increase or decrease gene expression. C)They are a type of cis-acting element. D)They bind only to promoters.arrow_forwardWhat is the advantage of using the neo gene to disrupt the function of a gene in knockout mice? a. The neo gene produces an antibiotic that kills unwanted cells. b. The neo gene is the right size for disabling other genes. c. The neo gene provides a selectable marker for finding cells that contain the disabled gene. d. The neo gene produces a toxin that inhibits transcription of the target genearrow_forward
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