Concept explainers
(a)
To determine: The structure of intermediate which is accumulated when respiration is stopped
Introduction:
Mitochondria is the primary site of
Given:
(b)
To explain: The reason of intermediate accumulation.
Introduction:
Succinate dehydrogenase -plays a major role in cellular respiration that monitors oxygen level which is found in the inner mitochondrial membrane. In pseudo-hypoxia conditions (low oxygen level), succinate dehydrogenate generates signals and send them to brain. It is given that
(c)
To explain: The reason why the oxygen consumption stops.
Introduction:
All the
(d)
To explain: The method to overcome the inhibition of respiration in isolated mitochondria.
Introduction:
Malonate is a competitive inhibitor that inhibits the activity of succinate dehydrogenase. Due to malonate activity, respiration stops eventually. To overcome the effect of the inhibition, it is sufficient to provide large amount of substrates such as succinate.
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