Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 16, Problem 39CTQ
New drugs are being developed that decrease DNA methylation and prevent the removal of acetyl groups from histone proteins. Explain how these drugs could affect gene expression to help kill tumor cells.
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New drugs are being developed that decrease DNA methylation and prevent the removal of acetyl groups from histone Explain how these drugs could affect gene expression to help kill tumor cells.
What common mutation occurs in many human cancers? Explain how it can have this effect.
The tumor suppressor pRB also binds to and suppresses the activity of retinoblastoma-binding protein 2 (RBP2), a histone demethylase that removes methyl groups from di- and trimethylated lysines in histone 3. What is the possible consequence of an inactivating mutation in RB1 that causes an inability of pRB to bind RBP2?
Chapter 16 Solutions
Biology 2e
Ch. 16 - Figure 16.5 In E. coli, the tip operon is on by...Ch. 16 - Figure 16.7 In females, one of the two X...Ch. 16 - Figure 16.13 An increase in phosphorylation levels...Ch. 16 - Control of gene expression in eukaryotic cells...Ch. 16 - Post-translational control refers to: regulation...Ch. 16 - How does the regulation of gene expression support...Ch. 16 - If glucose is absent, but so is lactose, the lac...Ch. 16 - Prokaryotic cells lack a nucleus. Therefore, the...Ch. 16 - The a/a operon is an inducible operon that...Ch. 16 - What are epigenetic modifications? the addition of...
Ch. 16 - Which of the following are true of epigenetic...Ch. 16 - The binding of _____ is required for transcription...Ch. 16 - What will result from the binding of a...Ch. 16 - A scientist compares the promoter regions of two...Ch. 16 - Which of the following are involved in post...Ch. 16 - Binding of an RNA binding protein will the...Ch. 16 - An unprocessed pre-mRNA has the following...Ch. 16 - IS. Alternative splicing has been estimated to...Ch. 16 - Post-translational modifications of proteins can...Ch. 16 - A scientist mutates elF-2 to eliminate its GTP...Ch. 16 - Cancer causing genes are called transformation...Ch. 16 - Targeted therapies are used in patients with a set...Ch. 16 - Name two differences between prokaryotic and...Ch. 16 - Describe how controlling gene expression will...Ch. 16 - Describe how transcription in prokaryotic cells...Ch. 16 - What is the difference between a repressible and...Ch. 16 - In cancer cells, alteration to epigenetic...Ch. 16 - A scientific study demonstrated that rat mothering...Ch. 16 - Some autoimmune diseases show a positive...Ch. 16 - A mutation within the promoter region can alter...Ch. 16 - What could happen if a cell had too much of an...Ch. 16 - A scientist identifies a potential transcription...Ch. 16 - Describe how RBPs can prevent miRNAs from...Ch. 16 - How can external stimuli alter...Ch. 16 - Protein modification can alter gene expression in...Ch. 16 - Alternative forms of a protein can be beneficial...Ch. 16 - Changes in epigenetic modifications alter the...Ch. 16 - A scientist discovers a virus encoding a Protein X...Ch. 16 - New drugs are being developed that decrease DNA...Ch. 16 - How can understanding the gene expression pattern...
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- Please choose the correct answer. If nutritional requirements are not met, gene expression will most likely be regulated a. before transcription factors enter the nucleus. b. before ubiquitin promotes proteolytic degradation. c. before translation initiation factors perform their tasks. d. before transcription factors have undergone multimerization.arrow_forwardDNA methylation status is associated with transcriptional activity. First, describe the specific mechanism by which DNA methylation can control gene activation. Next, hypothesize what would happen to transcription in a cell that expressed an nonfunctional maintenance methyltransferase. Please give me long detailed answer.arrow_forwardEpigenetic marks regulate gene expression. Which epigenetic mark is NOT associated with positive gene expression? A. Histone acetylation B. Histone Methylation C. De-methylated DNA D. Methylated DNAarrow_forward
- Cancer cells removed from a patient's tumor have increased gene expression of several hundred genes (including many cancer-causing genes). Scientists determine that the histones from the cancer cells have an overall/average lower affinity for DNA than histones from normal control cells. Which drug is most likely to help treat this patient's cancer? a. An inhibitor for HMT (histone methyltransferases) b. An inhibitor for HDM (histone demethylases) c. An inhibitor for HDACs (histone deacetylases) d. An inhibitor for HATs (histone acetyltransferase)arrow_forwardMatch the type of chromatin modification with the most likely effect on gene expression near the modified region. Each answer will be used once. -Increased expression -decreased expression -may increase or decrease expression a)Histone acetylation b)Histone methylation c)CpG methylationarrow_forwardAlthough tobacco smoking is responsible for a large number of human cancers, not all smokers develop cancer. Similarly, some people who inherit mutations in the tumor-suppressor genes p53 or RB1 never develop cancer. Explain these observations.arrow_forward
- Modifications of histone tails to gain access to a gene is known as ______. Chromatin modifications DNA methylation Post-transcriptional processing Post-translational modificationsarrow_forwardSome cancers have been treated with drugs that demethylate DNA.Explain how these drugs might work. Do you think the cancer-causinggenes that responded to the demethylation are likely to have beenoncogenes or tumor-suppressor genes? Explain your reasoning.arrow_forwardPossible genetic modifications that can cause epigenetic changes in gene expression include: A- all answers are correct B- histone acetylation C- chromatin remodeling D- histone variant localization  e- DNA methylationarrow_forward
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