Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 16.5, Problem 3SB
Summary Introduction

To review:

The normal function of the proto-oncogenes and the way mutations in the proto-oncogenes contribute to the production of cancer.

Introduction:

Any change in the genetic material of an individual, which is of permanent nature, is referred to as mutation. One kind of mutation is base-pair mutation, which involves the alteration of a single base pair in the genetic material. There are two kinds of cells, namely tumor suppressor genes and proto-oncogenes.

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Why does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a cancerous phenotype, while it takes two mutations in tumor suppressor genes to lead to a cancerous phenotype?
Why are oncogenes usually dominant in their action, whereas tumor-suppressor genes are recessive?
What are proto-oncogenes, oncogenes, and tumor suppressor genes and what is their involvement in cancer?
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