Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 16, Problem 12TYK
Summary Introduction
To review:
Fruit flies possess a mutation in the tumor suppressor gene HIPPO, which is homozygous and leads to the development of tumors in every organ. The expression of the human gene, MST2 in flies with the homozygous mutation in the HIPPO gene leads to a great reduction in the development of tumors. Further, the evolution of tumor suppressor genes in animals is also to be assessed.
Introduction:
Tumor suppressor genes are present in all cells of animals and the product of these genes are called tumor suppressor proteins, which participate in the regulation of cell growth by inhibiting excessive growth of the cell.
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Some cancers have been treated with drugs that demethylate DNA.Explain how these drugs might work. Do you think the cancer-causinggenes that responded to the demethylation are likely to have beenoncogenes or tumor-suppressor genes? Explain your reasoning.
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Which of the following statements correctly describes a characteristic of tumor-suppressor gene?
a) they are frequently overexpressed in cancerous cells.
b) they are cancer-causing genes introduced into cells by viruses.
c) they encode proteins that help prevent uncontrolled cell growth.
d) they often encode proteins that stimulate the cell cycle.
Chapter 16 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 16.1 - Suppose the lacl gene is mutated so that the Lac...Ch. 16.1 - Answer the equivalent question for the trp operon:...Ch. 16.2 - What is the role of histones in gene expression?...Ch. 16.2 - Prob. 2SBCh. 16.3 - Prob. 1SBCh. 16.3 - Prob. 2SBCh. 16.4 - Prob. 1SBCh. 16.4 - Prob. 2SBCh. 16.5 - Prob. 1SBCh. 16.5 - Prob. 2SB
Ch. 16.5 - Prob. 3SBCh. 16.5 - Prob. 4SBCh. 16 - Prob. 1TYKCh. 16 - For the E. coli lac operon, when lactose is...Ch. 16 - Prob. 3TYKCh. 16 - Prob. 4TYKCh. 16 - Prob. 5TYKCh. 16 - Prob. 6TYKCh. 16 - Prob. 7TYKCh. 16 - Prob. 8TYKCh. 16 - Prob. 9TYKCh. 16 - Prob. 10TYKCh. 16 - Discuss Concepts In a mutant strain of E. coli,...Ch. 16 - Prob. 12TYKCh. 16 - Prob. 13TYKCh. 16 - Prob. 14TYKCh. 16 - Design an experiment using rats as the model...Ch. 16 - Prob. 1ITDCh. 16 - Prob. 2ITDCh. 16 - Prob. 3ITDCh. 16 - Prob. 4ITD
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which of the following statements about cancer is false? (a) oncogenes arise from mutations in proto-oncogenes (b) tumor suppressor genes normally interact with growth-inhibiting factors to block cell division (c) more than 120 cancer-driving genes have been discovered (d) oncogenes were first discovered in mouse models for cancer (e) the development of cancer is usually a multistep process involving both oncogenes and mutated tumor suppressor genesarrow_forwardA research study indicated that an agent in cigarette smoke caused the silencing of a tumor suppressor gene called p53. However,upon sequencing, no mutation was found in the DNA sequence for this gene. Give two possible explanations for these results.arrow_forwardBAX proteins stimulate apoptosis. Mutations in BAX genes can help developing cancers but not necessarily trigger a tumor. This is because mutations in BAX do not contribute to tumorigenesis, but BAX can prevent the formation of a tumor mutations in BAX may over-stimulate apoptosis mutations in BAX contribute to tumorigenesis only with other inhibitors of apoptosis mutations in BAX prevent the formation of tumorsarrow_forward
- Which of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogenearrow_forwardCells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene therapy can be used to introduce a normal copy of this gene into the tumor cells. Would you expect this therapy to be effective if the mutated gene were an oncogene? A tumor-suppressor gene? Explain your reasoning.arrow_forwardBAX proteins stimulate apoptosis. Mutations in BAX genes can help developing cancers but not necessarily trigger a tumor. This is because a. mutations in BAX do not contribute to tumorigenesis, but BAX can prevent the formation of a tumor b. mutations in BAX may over-stimulate apoptosis c. mutations in BAX contribute to tumorigenesis only with other inhibitors of apoptosis d. mutations in BAX prevent the formation of tumorsarrow_forward
- Imagine you have used cBioportal and breast cancer patient datasets and identified a cancer-associated mutation in a particular protein. What would you do next to understand whether that mutation contributes to tumor progression (include experimental approach)?arrow_forwardIn your own words: Describe the molecular mechanisms involved in P53’s role as a tumor repressor protein.arrow_forwardWhich of the following best describes a gene that codes for a tumor-suppressor protein? a. One that helps to prevent progression through the cell cycle. b. One that helps prevent apoptosis. c. One that codes for a DNA repair enzyme. d. One that supports part of a growth factor signaling pathway.arrow_forward
- Much remains unknown about the rapid, uncontrolled growth, or what causes a tumor to metastasize. Scientists do know that cancer cells come from normal healthy cells that have had some type of damage done to the genes that aid in the production of the regulatory proteins for the cell cycle. What causes this damage? a proto-oncogenes b mutations c enzymes d tumor suppressorsarrow_forwardApart from p53, mention and describe the function of three tumor suppressor genes you knowarrow_forwardCharacterize the differences between tumor cells and normal cells in terms of the following properties. In cancer cells, how might each of these properties contribute to tumor progression? a) contact inhibition b) autocrine stimulation c) apoptosis d) senescence due to telomere shortening e) genomic stability f) angiogenises g) metastasisarrow_forward
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