Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 16.5, Problem 5R
Summary Introduction
To review:
The function of miRNA (micro ribonucleic acids) drugs in the treatment of cancer.
Introduction:
The miRNA are small RNA molecules that are involved in the gene expression regulation in various processes. These small RNAs play a considerable role in targeting pathways of human diseases. These are now attracted to pharmaceuticals for therapeutic interventions, especially for the treatment of cancer.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Explain why many oncogenic viruses contain genes whose products interact with tumor-suppressor proteins.
a. Why would a mutation in BRCA1 be considered a driver mutation?
b. Based on what you’ve learned thus far, would ATM be considered a tumor suppressor? Explain your reasoning.
In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an oncogene or a tumor-suppressor gene? Explain your reasoning
Chapter 16 Solutions
Life: The Science of Biology
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Assume that the provirus in Figure 23.14 inserts just upstream of atumor-suppressor gene. Would this insertion be likely to cause cancer?Why or why not?arrow_forwardWhich of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.arrow_forwardhow could deacetylation of proteins by sirtuins counteract the "information loss" seen in aging cells? a gene in a mammal with a promoter region that contains 5 CpGs per 100 nucleotides. What type of gene is thatarrow_forward
- What is the difference between a proto-oncogene and a tumor-suppressor gene?arrow_forwardIs PI3K a proto-oncogene or a tumor suppressor gene? Why?arrow_forwardWhy does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a cancerous phenotype, while it takes two mutations in tumor suppressor genes to lead to a cancerous phenotype?arrow_forward
- Cells in a tumor contain mutated copies of a particular gene that promotes tumor growth. Gene therapy can be used to introduce a normal copy of this gene into the tumor cells. Would you expect this therapy to be effective if the mutated gene were an oncogene? A tumor-suppressor gene? Explain your reasoning.arrow_forwardThe role of p53 in normal cells is toa. create cancer-blocking mutations.b. trigger unrestrained cell division.c. detect damaged DNA.d. splice exons together in the correct sequence.arrow_forwardChanges in a cell that affect micro RNAs lead to cancer because miRNAs... a. help a cell to maintain a tight control on protein levels in a cell. b. decrease the level of a specific protein. c. increase the level of a specific protein. d. prevent the Warburg effect.arrow_forward
- Based on Figure 17-35, write a sentence stating howtranslocation can lead to cancer. Can you think of another genetic cause of cancer?arrow_forwardIn DNA repair, how does the normal allele of BRCA1 work? Is it an oncogene or a tumor suppressor gene?arrow_forwardp53 is an activator of a miRNA called miR-145. miR-145 targets c-myc, a gene that promotes cellular proliferation and survival. If p53 undergoes a loss of functionmutation, what would be the overall result? Question 5 options: Increased proliferation and survival. Decreased proliferation and survival.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
An Introduction to the Human Genome | HMX Genetics; Author: Harvard University;https://www.youtube.com/watch?v=jEJp7B6u_dY;License: Standard Youtube License