Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 18, Problem 7TY
Summary Introduction
Introduction: The epigenetic changes refer to the changes that alter the gene expression but do not alter the sequence of DNA. The epigenetic changes can be caused as a result of environmental factors also and can result in the development of many diseases and disorders.
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Which of the following statements correctly describes a characteristic of tumor-suppressor gene?
a) they are frequently overexpressed in cancerous cells.
b) they are cancer-causing genes introduced into cells by viruses.
c) they encode proteins that help prevent uncontrolled cell growth.
d) they often encode proteins that stimulate the cell cycle.
Which of the following is true of tumor suppressor genes?
Group of answer choices
a) If this gene is overactive, it becomes an oncogene
b) If one of the alleles is mutated, there is usually little effect. Two inactivating mutations are usually required for loss of function (recessive mutation).
c) If one copy is lost, the gene no longer functions (dominant mutation)
d) Tumor suppressors genes usually cause mitosis or cell growth
e) Tumor suppressor genes decrease apoptosis
Compare and contrast oncogenes and tumor suppressors. Contrast oncogenes and proto-oncogenes. Describe the types of mutations that convert proto-oncogenes into oncogenes. Summarize some functions of common oncogenes in cell survival and uncontrolled growth. Contrast tumor suppressors to oncogenes. Describe the types of mutations in tumor suppressors that are found in common cancers. Summarize the functions of common tumor suppressors in cell survival and cell growth.
Chapter 18 Solutions
Biology
Ch. 18.2 - Prob. 1CCCh. 18.3 - Prob. 1CCCh. 18.3 - Prob. 1CSCh. 18.5 - Prob. 1CSCh. 18.5 - Prob. 1CCCh. 18.6 - Prob. 1EQCh. 18.6 - Prob. 2EQCh. 18.6 - Prob. 3EQCh. 18.6 - Prob. 1CCCh. 18.6 - Prob. 2CC
Ch. 18 - Which of the following is an example of an...Ch. 18 - Prob. 2TYCh. 18 - A female mouse that is Igf2 Igf2 is crossed to a...Ch. 18 - Prob. 4TYCh. 18 - Prob. 5TYCh. 18 - Prob. 6TYCh. 18 - Prob. 7TYCh. 18 - Prob. 8TYCh. 18 - Based on the ideas proposed by Morgan, which of...Ch. 18 - Extranuclear inheritance occurs because a. certain...Ch. 18 - Define epigenetics. Are all epigenetic changes...Ch. 18 - What is a Barr body? How is its structure...Ch. 18 - Core Concept: Information A core concept of...Ch. 18 - Prob. 1COQCh. 18 - Mendel studied seven traits in garden pea plants,...
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- Another model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?arrow_forwardWhich of the following statements about cancer is false? (a) oncogenes arise from mutations in proto-oncogenes (b) tumor suppressor genes normally interact with growth-inhibiting factors to block cell division (c) more than 120 cancer-driving genes have been discovered (d) oncogenes were first discovered in mouse models for cancer (e) the development of cancer is usually a multistep process involving both oncogenes and mutated tumor suppressor genesarrow_forwardThe p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene or a tumor-suppressor gene. Several years later, researchers showed that both p53 alleles are inactivated in some mouse cancers. This evidence suggests A. the p53 gene is an oncogene because inactivated alleles would produce mutated signal transduction proteins that would result in stimulating cell division. B. the p53 gene is an oncogene because the cell would overproduce transcription factors to compensate for the inactive alleles, resulting in increased cell division. C. the p53 gene is a tumor-suppressor gene because inactivated alleles indicate a loss of protein function which allowed the cancer to develop D. the p53 gene is a tumor-suppressor gene because the cell would produce too few transcription factors for gene activation, resulting in decreased cell division.arrow_forward
- Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene expected to behave as a recessive gene?arrow_forwardWhich of the following associated with cancer development would you expect to be tumor promoters and not genotoxic carcinogens (select all that apply)? A. Excessive alcohol consumption that kills liver cells B. Bisphenol A which mimics the activity of estrogen C. Chemical in pesticides that binds and activates a transcription factor that cause activation of NFkB D. Chemical in cigarette smoke that forms adduct with DNA E. A viral infection that causes ulcerative coilitis of GI tractarrow_forwardA. Which genes could be used to monitor the process of the disease? B.  If you worked for a drug company developing a treatment for the cancer, which genes would you target to turn on in cancer cells? C. Which genes would you target to turn off in cancer cells?arrow_forward
- Which of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogenearrow_forwardWhich of the following best describes a gene that codes for a tumor-suppressor protein? a. One that helps to prevent progression through the cell cycle. b. One that helps prevent apoptosis. c. One that codes for a DNA repair enzyme. d. One that supports part of a growth factor signaling pathway.arrow_forwardHow can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of genetic mutations in tumor-suppressor genes and proto-oncogenes?arrow_forward
- Gene expression array technology has been used to do which of the following (select all that apply)? A. Determine liklihood of metastasis B. Determine the most relevant treatment for individual patients based on their genomic “signature.” C. Determine therapeutic index of cancer drug D. Predict the likelihood of disease recurrence in individuals based on gene expression signatures E. Stratify patients with breast cancer into groups predictive of response to therapyarrow_forwardWhy does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a cancerous phenotype, while it takes two mutations in tumor suppressor genes to lead to a cancerous phenotype?arrow_forwardDistinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do proto-oncogenes and tumor-suppressor genes undergo gain-of-function or loss-of-function mutations? Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, BCL-2, JUN, MDM2, and p16.arrow_forward
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