Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 19.5, Problem 2COMQ
Which of the following DNA repair systems may involve the removal of a segment of a DNA strand?
a. Base excision repair
b.
c. Mismatch repair
d. All of the above
Expert Solution & Answer
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Nucleotide excision repair
A.
recognizes and repairs thymine dimers and other damaged bases in DNA
B.
corrects errors in nucleotide excision
C.
recognizes and removes mismatched bases after DNA synthesis is completed
D.
removes nucleotides that are incorrectly incorporated during DNA synthesis
Defects in the excision repair process may result in :
A. Mutations
B. Okazaki fragments
C. Excess DNA polymerase activity
D. Shortened telomeres
Which of the following statements describe reversal of DNA repair mechanism.
A. UV light blocks the translation of mRNA beyond the damaged area
B. Reversal of DNA repair mechanism requires a DNA template
C. UV light is needed to initiate the formation of pyrimidine dimers
D. None of the statement is correct
Chapter 19 Solutions
Genetics: Analysis and Principles
Ch. 19.1 - 1. A mutation changes a codon that specifies...Ch. 19.1 - A down promoter mutation causes the promoter of a...Ch. 19.1 - 3. A mutation in one gene that reverses the...Ch. 19.1 - Which of the following is an example of a somatic...Ch. 19.2 - Prob. 1COMQCh. 19.3 - Which of the following is not an example of a...Ch. 19.3 - A point mutation could be caused by a....Ch. 19.3 - One way that TNRE may occur involves the formation...Ch. 19.4 - Nitrous acid replaces amino groups with keto...Ch. 19.4 - Prob. 2COMQ
Ch. 19.4 - Prob. 3COMQCh. 19.5 - The function of photolyase is to repair a....Ch. 19.5 - Which of the following DNA repair systems may...Ch. 19.5 - 3. In nucleotide excision repair in E. coli, the...Ch. 19.5 - Prob. 4COMQCh. 19.5 - An advantage of translesion-replicating...Ch. 19 - Is each of the following mutations a transition,...Ch. 19 - Prob. 2CONQCh. 19 - What does a suppressor mutation suppress? What is...Ch. 19 - Prob. 4CONQCh. 19 - X-rays strike a chromosome in a living cell and...Ch. 19 - Prob. 6CONQCh. 19 - Prob. 7CONQCh. 19 - 8. A point mutation occurs in the middle of the...Ch. 19 - Prob. 9CONQCh. 19 - Prob. 10CONQCh. 19 - 11. Is a random mutation more likely to be...Ch. 19 - 12. Which of the following mutations could be...Ch. 19 - Prob. 13CONQCh. 19 - Discuss the consequences of a germ-line versus a...Ch. 19 - Prob. 15CONQCh. 19 - Explain how a mutagen can interfere with DNA...Ch. 19 - What type of mutation (transition, transversion,...Ch. 19 - Explain what happens to the sequence of DNA during...Ch. 19 - Distinguish between spontaneous and induced...Ch. 19 - Prob. 20CONQCh. 19 - Prob. 21CONQCh. 19 - Prob. 22CONQCh. 19 - Trinucleotide repeat expansions (TNREs) are...Ch. 19 - 24. With regard to TNRE, what is meant by the term...Ch. 19 - 25. What is the difference between the mutation...Ch. 19 - Achondroplasia is a rare form of dwarfism. It is...Ch. 19 - Prob. 27CONQCh. 19 - In the treatment of cancer, the basis for many...Ch. 19 - Prob. 29CONQCh. 19 - 30. Which of the following examples is likely to...Ch. 19 - Prob. 31CONQCh. 19 - Prob. 32CONQCh. 19 - Prob. 33CONQCh. 19 - With regard to the repair of double-strand breaks,...Ch. 19 - Prob. 35CONQCh. 19 - Prob. 36CONQCh. 19 - 37. Three common ways to repair changes in DNA...Ch. 19 - Prob. 38CONQCh. 19 - Prob. 39CONQCh. 19 - Explain how the technique of replica plating...Ch. 19 - 2. Outline how you would use the technique of...Ch. 19 - 3. From an experimental point of view, is it...Ch. 19 - Prob. 4EQCh. 19 - Prob. 5EQCh. 19 - 6. Richard Boyce and Paul Howard-Flanders...Ch. 19 - In E. coli, a variety of mutator strains have been...Ch. 19 - 2. Discuss the times in a person’s life when it is...Ch. 19 - A large amount of research is aimed at studying...
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- Which of the following mechanisms is involved in double-strand DNA repair? a. Homology-dependent repair b. Nonhomologous end joining c. Mismatch repair d. A and B e. A, B, and Carrow_forwardWhich of the following would be most likely to cause a mutation? A. the addition of nucleotides to the 3’ end of the growing strand B. the insertion of a mismatched nucleotide into a DNA strand C. the unwinding of the DNA strand D. the synthesis of short stretches of DNAarrow_forwardDNA damage by uv light creates pyrimidine dimers between adjacent pyrimidines on the same strand. The cellular mechanism used to repair these dimers is : A. Mismatch repair B. Proofreading C. Nucleotide Excision Repair D. Single- base excisionarrow_forward
- Which type of cells were used to extract the DNA that was sequenced? a. red blood cells c. white blood cells b. intestinal epithelium d. cheek swab What type of mutation caused Nicholas’s disease? a. frameshift c. nonsense b. missense d. insertionarrow_forwardA.) Damaged DNA can be reversed if nucleotides can be replaced with a proper nucleotide for a correct amino acid base. B.) Direct reversal of DNA repair can destroy the abnormal bonds of the nucleotides in the DNA sequence. a. Statement A is correct b. Statement B is correct c. Both A and B are correct d. Both A and B are incorrectarrow_forwardWhat repair system will have an issue functioning properly if DNA glycosylase loses its function? A. Photoreactivation repair B. Base excision repair C. Nucleotide excision repair D. SOS repairarrow_forward
- The initial mechanism for repairing nucleotide errors in DNA is _____. a. mismatch repair b. DNA polymerase proofreading c. nucleotide excision repair d. thymine dimersarrow_forwardThe phrase 5to3 refers to the _________ . a. timing of DNA replication b. directionality of DNA synthesis c. number of phosphate groupsarrow_forwardWhich of the following statements applies to both point and frameshift mutations? A. A base is removed from a DNA template strand B. A base is added to a DNA template strand C. A base is substituted for another base in a DNA template strand D. No correct responsearrow_forward
- What can cause mutations in the DNA sequence? Select all that apply. a.Exposure of cells to ionizing radiation b.Failure of repair enzymes to recognize mismatched nucleotides before and during DNA replication c.Recognition of mismatched bases by repair enzymes before and during DNA replication d.Nucleotide errors occurring during DNA replicationarrow_forwardWhat can cause mutations in the DNA sequence? Select all that apply. A. Failure of repair enzymes to recognize mismatched nucleotides before and during DNA replication B. Recognition of mismatched bases by repair enzymes before and during DNA replication C. Exposure of cells to ionizing radiation D. Nucleotide errors occurring during DNA replicationarrow_forwardWhat is DNA polymerase? a.An enzyme that carries out DNA replication b.Short, single strand of DNA that base-pairs with a specific DNA sequence c.An enzyme that corrects mutations that arise during the replication of DNA d.An enzyme that seals any gaps that remain between bases of replicating strands of DNAarrow_forward
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