Interpretation:
In a Gabriel synthesis, the yield of the
Concept introduction:
In the Gabriel synthesis, phthalimide is first treated with a strong base such as potassium hydroxide, followed by an
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Organic Chemistry: Principles and Mechanisms (Second Edition)
- Can someone help me with retro - synthesis, also can you do a detailed step by step with mechanisms to help me understand how you got the answer and what each reagent does.arrow_forwardHelp. Please order these compounds from the fastest rate of acid-catalyzed hydrolysis to give acetic acid, to the slowest.arrow_forwardPlease answer this NEATLY, COMPLETELY, and CORRECTLY for an UPVOTE. Arrange the intermediates below in order of increasing basicity:arrow_forward
- Which starting materials will result in the below product through a reductive amination reaction? The correct answer is C, but please explain why:)arrow_forwardIn benzoic acid, when it has a deactivating group in position "para" (relative to carboxylate position) , it attracts electrons towards it, weakening the acid and an activator pushes the electrons making the acid stronger.What happens to this benzoic acid if it has a substituent at the "meta" or "ortho" position as an activator or a deactivator? I need an explanation of what happens in each case pleasearrow_forwardAmides are weak nucleophiles but their conjugate bases are string nucleophiles. The amide drawn below can be deprotonated in four possible locations, labeled A-D but two are considerably more acidic than the others. Draw the two different Bronsted Lowery acid/base reactions (using HO- as the BL base) showing the deprotonation at these two locations. Draw all RS with arrows for both conjugate bases but no hybrids. Based on your resonance analysis which location is the most acidic in the molecule? Why is it most acidic? Amides can also be protonated by a strong acid in two different locations. Draw two different conjugate acids for the amide above as well as RS with arrows for each. Based on your resonance analysis which atom is the most basic in an amide?arrow_forward
- The product in this reaction is basic enough to be protonated by a dilute HCl solution. Draw the protonated species, clearly showing where protonation occurs. Draw all possible resonance structures of the conjugate acid of the product, and use these to explain why the product is so much more basic than a typical ester, like ethyl acetate.arrow_forwardHow can I design a multi-step synthesis for the following:arrow_forwardPlease show me how to perform the following synthesisarrow_forward
- Please help with the retrosynthesis of this target molecule. Thank you!arrow_forwardWhich would be the best way to carry out the following synthesis?arrow_forwardFor each statement below, label it as causing a faster or slower rate for an E1 reaction. If it doesn’t effect rate at all then label it as neither. Stronger base Increase base concentration Switch leaving group from Cl to I Switch leaving group from 2˚ to 3˚arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning