EP ORGANIC CHEMISTRY -MOD.MASTERING 18W
EP ORGANIC CHEMISTRY -MOD.MASTERING 18W
9th Edition
ISBN: 9780136781776
Author: Wade
Publisher: PEARSON CO
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Chapter 20.15, Problem 20.23P
Interpretation Introduction

Interpretation:

The mechanism for the nucleophilic acyl substitution to form ethyl benzoate and Nmethylacetamide is to be shown.

Concept introduction:

Nucleophilic acyl substitution reactions are the type of substitution reactions that comprise acyl compounds as the reactants along with nucleophile that attacks on electron deficient atoms in the compounds. The synthesis of compound relies upon the type of reactants and reagents that are used during the reactions.

The energy of the product should be low because low energy of a compound increases the stability of a compound. The stability of a compound is the major factor that is responsible for the formation of a compound. The reagents perform numerous functions in reactions like proton abstraction, oxidation, reduction, catalysis, and dehydrogenation.

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Based on the image attached, it shows methyl salicylate reacts with Ethanamine, and Ether act as a solvent to form N-ethylbenzamide as a product. Explains the mechanism reaction of conversion ester to an amide.
Rank the following esters from most reactive to least reactive in the first slow step of a nucleophilic acyl substitution reaction (formation of the tetrahedral intermediate): Rank the same esters from most reactive to least reactive in the second slow step of a nucleophilic acyl substitution reaction (collapse of the tetrahedral intermediate).
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EP ORGANIC CHEMISTRY -MOD.MASTERING 18W

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