Interpretation:
The complete, detailed mechanism for the synthesis of aspirin from salicylic acid and acetic ahnhdride is to be drawn. The strucure of the product is to be drawn.
Concept introduction:
Carboxylic acid derivatives undergo acyl group substitution reactions when treated with appropriate nucleophiles. The reaction occurs via nucleophilic addition-elimination involving a tetrahedral intermediate. It may also involve proton transfer step(s), paticularly when the nucleophile being added in the first step is not a strong nucleophile. The reaction occurs if the possible product is more stable than the reactant. If the two are of comparable stability, the reaction will occur reversibly. The order of increasing stability of acid derivatives is
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