Essentials of Genetics (9th Edition) - Standalone book
Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 22, Problem 26PDQ

Comparisons of Neanderthal mitochondrial DNA with that of modern humans indicate that they are not related to modern humans and did not contribute to our mitochondrial heritage. However, because Neanderthals and modern humans are separated by at least 25,000 years, this does not rule out some forms of interbreeding causing the modern European gene pool to be derived from both Neanderthals and early humans (called Cro-Magnons). To resolve this question, Caramelli et al. (2003. Proc. Natl Acad Sci. [USA] 100: 6593–6597) analyzed mitochondrial DNA sequences from 25,000–year-old Cro-Magnon remains and compared them to four Neanderthal specimens and a large dataset derived from modern humans. The results are shown in the graph.

Chapter 22, Problem 26PDQ, Comparisons of Neanderthal mitochondrial DNA with that of modern humans indicate that they are not

The x-axis represents the age of the specimens in thousands of years; the y-axis represents the average genetic distance. Modern humans are indicated by filled squares; Cro-Magnons, open squares; and Neanderthals, diamonds.

(a) What can you conclude about the relationship between Cro-Magnons and modern Europeans? What about the relationship between Cro-Magnons and Neanderthals?

(b) From these data, does it seem likely that Neanderthals made any mitochondrial DNA contributions to the Cro-Magnon gene pool or the modern European gene pool?

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Students have asked these similar questions
Once nuclear DNA sequencing became fast and able to handle sequencing ancient DNA, living humans were found to have some Neanderthal genes.  Is this finding clear evidence that some early modern humans did indeed hybridize with Neanderthals?  Why?
How does the fact that all ethnic groups except Africans contain some Neanderthal DNA (1–4 percent of their DNA) support the out-of-Africa hypothesis for the origin of modern humans (Homo sapiens)?
If phenotype is a proxy for genotype, then why do you think that paleoanthropologists erroneously designated Neandertalensis as a separate species prior to the accessibility of DNA analysis?  What were they comparing them to when they were lumping or splitting fossils taxonomically and why would these reference populations provide the bias resulting in such a confounding factor in their assessments?

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