(a) Interpretation: The deficiency of pyruvate hydrogenase is characterized as neurological dysfunction. The reason for this statement should be determined. Concept introduction: Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

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Answer 1

Question

Chapter 22, Problem 55P

Interpretation Introduction

(a)

Interpretation:

The deficiency of pyruvate hydrogenase is characterized as neurological dysfunction. The reason for this statement should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(b)

Interpretation:

The reason for lactic acidosis should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(c)

Interpretation:

The reason for low-carbohydrate diet should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

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Students have asked these similar questions

Long explanations are not needed. Direct answers would suffice. a. High concentration of glucose 6-phosphate is inhibitory to the enzyme hexokinase. I. True II. False b. Which compound is formed when NAH reduces pyruvate (anaerobic condition)? I. lactate II. alpha-ketoglutarate III. glucose IV. oxaloacetate

Long explanations are not needed. Direct answers would suffice. a. Ribose-5-phosphate is produced by oxidative decarboxylation of 6-phosphogluconate catalyzed by the enzyme glucose-6-phosphate dehydrogenase. I. True II. False b. The pentose phosphate pathway occurs in the mitochondrion of tissues actively engaged in synthesis of fatty acids. I. True II. False

Need help, please. In this scenario, a patient has beriberi. Beriberi patients can be treated through a thiamine-enriched diet. The patient was put on a thiamine-enriched diet but not all of their symptoms were alleviated. Through genetic testing, it was found that there was also a small defect in pyruvate dehydrogenase phosphatase that decreases its normal activity. 1. Explain why this genetic defect can cause beriberi symptoms (i.e. high pyruvate levels after a high-carb meal). 2. Why did thiamine supplementation not alleviate the symptoms for this patient?

Answer 2

Question

Chapter 22, Problem 55P

Interpretation Introduction

(a)

Interpretation:

The deficiency of pyruvate hydrogenase is characterized as neurological dysfunction. The reason for this statement should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(b)

Interpretation:

The reason for lactic acidosis should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(c)

Interpretation:

The reason for low-carbohydrate diet should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

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Answer 3

Question

Chapter 22, Problem 55P

Interpretation Introduction

(a)

Interpretation:

The deficiency of pyruvate hydrogenase is characterized as neurological dysfunction. The reason for this statement should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(b)

Interpretation:

The reason for lactic acidosis should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(c)

Interpretation:

The reason for low-carbohydrate diet should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

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Answer 4

Question

Chapter 22, Problem 55P

Interpretation Introduction

(a)

Interpretation:

The deficiency of pyruvate hydrogenase is characterized as neurological dysfunction. The reason for this statement should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(b)

Interpretation:

The reason for lactic acidosis should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(c)

Interpretation:

The reason for low-carbohydrate diet should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

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Answer 5

Chapter 22, Problem 55P

Interpretation Introduction

(a)

Interpretation:

The deficiency of pyruvate hydrogenase is characterized as neurological dysfunction. The reason for this statement should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(b)

Interpretation:

The reason for lactic acidosis should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Interpretation Introduction

(c)

Interpretation:

The reason for low-carbohydrate diet should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Answer 6

Chapter 22, Problem 55P

Interpretation Introduction

(a)

Interpretation:

The deficiency of pyruvate hydrogenase is characterized as neurological dysfunction. The reason for this statement should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Answer 7

Chapter 22, Problem 55P

Interpretation Introduction

(a)

Interpretation:

The deficiency of pyruvate hydrogenase is characterized as neurological dysfunction. The reason for this statement should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The reason for lactic acidosis should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The reason for lactic acidosis should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Answer 10

Interpretation Introduction

(c)

Interpretation:

The reason for low-carbohydrate diet should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Answer 11

Interpretation Introduction

(c)

Interpretation:

The reason for low-carbohydrate diet should be determined.

Concept introduction:

Lactic acidosis is a medical condition, which is caused due to the buildup of lactate in the body. Excess of lactate in the blood also leads to low pH levels in the body. The signs and symptoms of lactic acidosis are discomfort, decreased appetite, diarrhea, and muscle pain.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 22 - Prob. 1P Ch. 22 - Prob. 2P Ch. 22 - Prob. 3P Ch. 22 - Prob. 4P Ch. 22 - Prob. 5P Ch. 22 - Prob. 6P Ch. 22 - Prob. 7P Ch. 22 - Prob. 8P Ch. 22 - Prob. 9P Ch. 22 - Prob. 10P

Solution Summary: The author explains that lactic acidosis is a medical condition caused by the buildup of lactate in the body. Lack of pyruvate dehydrogenase would result in improper oxidation of

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