(a)
Interpretation:
The method for the synthesis of given ketone has to be stated with the help of acetoacetic ester synthesis.
Concept introduction:
The final products of acetoacetic ester synthesis are
(b)
Interpretation:
The method for the synthesis of given ketone is to be stated with the help of acetoacetic ester synthesis.
Concept introduction:
The final products of acetoacetic ester synthesis are ketones, specially substituted derivatives of acetone. In acetoacetic ester synthesis, substituents are added to the enolate ion of acetoacetic ester. Then, hydrolysis takes place followed by decarboxylation to give alkylated derivatives of acetone.
(c)
Interpretation:
The method for the synthesis of given ketone is to be stated with the help of acetoacetic ester synthesis.
Concept introduction:
The final products of acetoacetic ester synthesis are ketones, specially substituted derivatives of acetone. In acetoacetic ester synthesis, substituents are added to the enolate ion of acetoacetic ester. Then, hydrolysis takes place followed by decarboxylation to give alkylated derivatives of acetone.
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Organic Chemistry (9th Edition)
- Which of the following conversions can be accomplished through an acetoacetic ester or malonic ester synthesis?arrow_forwardPropose a mechanism for conversion of the dianion to the ketone under mildly acidic conditions.arrow_forwardHow would you synthesize the methyl ketone shown below via the acetoacetic ester synthesis? You must show the reactions/reagents used in their correct orderarrow_forward
- Show how the following compounds can be made using the malonic ester synthesis.(a) 3-phenylpropanoic acidarrow_forwardPropose an efficient synthesis for the following transformations using ONLY malonic ester synthesis.arrow_forwardPropose a multi-step synthesis pathway to create the indicated products. Use the following substrates as your only source of carbon. Utilize the acetylide ion method to form the new carbon-carbon bond.arrow_forward
- Show how the following compound can be prepared by a malonic or acetoacetic ester synthesis (or other B-dicarbonyl) reaction:arrow_forwardPropose preparative routes to the following ketones using an enamine intermediate - you must make the bond highlighted in red:arrow_forwardShow how the acetoacetic ester synthesis is used to make 3-propylhex-5-en-2-one.Sarrow_forward
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