Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 26, Problem 18CONQ
Explain how loss-of-function mutations in the following categories of genes would affect the morphologies of Drosophila larvae:
A. Gap genes
B. Pair-rule genes
C. Segment-polarity genes
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Describe the role of coordinate genes, gap genes, pair rule genes, segment polarity genes, and homeotic genes in Drosophila development.
Here are schematic diagrams of mutant Drosophila larvae.
The left side of each pair shows a wild-type larva, with gray boxes showing the sections that are missing in the mutant larva. Which type of gene is defective in each larva: a gap gene, a pair-rule gene, or a segment-polarity gene?
What is the difference between a maternal-effect gene and a zygotic gene? Of the following genes that play a role in Drosophila development, which are maternal-effect genes and which are zygotic? Explain your answer.
A. nanos
B. Antp
C. bicoid
D. lab
Chapter 26 Solutions
Genetics: Analysis and Principles
Ch. 26.1 - Prob. 1COMQCh. 26.1 - Prob. 2COMQCh. 26.1 - Which of the following is the correct order for...Ch. 26.2 - Prob. 1COMQCh. 26.2 - Prob. 2COMQCh. 26.2 - Prob. 3COMQCh. 26.2 - Prob. 4COMQCh. 26.3 - Prob. 1COMQCh. 26.3 - Prob. 2COMQCh. 26.3 - 3. Myogenic bHLH proteins are ___________ that...
Ch. 26.4 - Prob. 1COMQCh. 26.4 - Prob. 2COMQCh. 26.5 - 1. A key event that initially determines female or...Ch. 26.5 - Prob. 2COMQCh. 26 - 1. What four types of cellular processes must...Ch. 26 - Prob. 2CONQCh. 26 - Prob. 3CONQCh. 26 - 4. Which of the following statement(s) is/are true...Ch. 26 - Discuss the morphological differences between the...Ch. 26 - Prob. 6CONQCh. 26 - Explain what a morphogen is, and describe how it...Ch. 26 - 8. What is positional information? Discuss three...Ch. 26 - Prob. 9CONQCh. 26 - Prob. 10CONQCh. 26 - 11. Describe the function of the Bicoid protein....Ch. 26 - With regard to development, what are the roles of...Ch. 26 - Discuss the role of homeotic genes in development....Ch. 26 - Describe the molecular features of the homeobox...Ch. 26 - What would you predict to be the phenotype of...Ch. 26 - Prob. 16CONQCh. 26 - If a mutation in a homeotic gene produced the...Ch. 26 - 18. Explain how loss-of-function mutations in the...Ch. 26 - What is the difference between a maternal-effect...Ch. 26 - Prob. 20CONQCh. 26 - Prob. 21CONQCh. 26 - Prob. 22CONQCh. 26 - 23. Discuss the similarities and differences...Ch. 26 - 24. What is cell differentiation? Discuss the role...Ch. 26 - Prob. 25CONQCh. 26 - What is a totipotent cell? In each of the...Ch. 26 - 27. What is a meristem? Explain the role of...Ch. 26 - Prob. 28CONQCh. 26 - Predict the phenotypic consequences of each of the...Ch. 26 - 30. Explain how alternative splicing affects sex...Ch. 26 - Prob. 1EQCh. 26 - Compare and contrast the experimental advantages...Ch. 26 - 3. What is meant by the term cell fate? What is a...Ch. 26 - 4. Explain why a cell lineage diagram is necessary...Ch. 26 - Explain the rationale behind the use of the bag of...Ch. 26 - Prob. 6EQCh. 26 - Take a look at question 2 in More Genetic TIPS...Ch. 26 - All of the homeotic genes inDrosophilahave been...Ch. 26 - Prob. 9EQCh. 26 - wo techniques commonly used to study the...Ch. 26 - Prob. 11EQCh. 26 - Prob. 12EQCh. 26 - 13. Another way to study the role of proteins...Ch. 26 - 14. Why have geneticists used reverse genetics to...Ch. 26 - Prob. 1QSDCCh. 26 - Prob. 2QSDCCh. 26 - Prob. 3QSDC
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- What would be the most likely effect on development of puncturing the posterior end of a Drosophila egg, allowing a small amount of cytoplasm to leak out, and then injecting that cytoplasm into the anterior end of another egg?arrow_forwardSeveral Drosophila species with unspotted wings are descended from a spotted ancestor. Would you predict the loss of spot formation to entail coding or noncoding changes in pigmentation genes? How would you test which is the case?arrow_forwardexplain Position-effect variegation in Drosophila?arrow_forward
- provide one example from the Drosophila AP toolkit for "Toolkit genes can be classified according to the phenotypes caused by their mutation. Similar mutant phenotypes often reflect genes that function in a single developmental pathway. Distinct pathways exist for the generation of body axes, for example, and for the formation and identity of fields."arrow_forwardWhich of the following molecular events is NOT involved in Drosophila ventralization? a. Easter protein splits spatzle protein. b. Snake protein cleaves easter protein. c. Spatzle protein cleaves nudel protein. d. Gastrulation defective (gd) protein splits snake protein Which of the following molecular events is NOT true of drosophila segmentation?* a. Hox genes define the identity of each segment. b. Gap genes define several broad areas. c. Pair rule genes define segment locations. d. Maternal effect genes determine segment boundaries. The dextral orientation of organs is promoted by which of the following molecular events?* a. activation of torso gene by acron ligands b. activation of Tube and Pelle proteins by Toll protein c. phosphorylation of the cactus protein by Tube and Pelle d. activation of myosin 1D gene by Hox gene abdominal-B protein Activation of the goosecoid gene for dorsalization does NOT…arrow_forwardA number of genes that control expression of Hox genes in Drosophila have been identified. One of these homozygous mutants is extra sex combs, where some of the head and all of the thorax and abdominal segments develop as the last abdominal segment. In other words, all affected segments develop as posterior segments. What does this phenotype tell you about which set of Hox genes is controlled by the extra sex combs gene?arrow_forward
- A maternal effect gene in Drosophila, called torso, is found as a recessive allele that prevents the correct development of anterior- and posterior-most structures. A wild-type (homozygous) male is crossed to a female of unknown genotype. This mating produces 100% larva that are missing their anterior- and posterior-most structures and therefore die during early development. What is the genotype and phenotype of the female fly in this cross? What are the genotypes and phenotypes of the female fly’s parents? Show COMPLETE cross.arrow_forwardWhat is positional information? What are three different ways that cells obtain positional information? Which of these ways do you think is the most important for the formation of a segmented body pattern in Drosophila?arrow_forwardDominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network? (c) Are genetic networks likely to specify developmental processes in general? Explain fully and provide an example.arrow_forward
- Which Position-effect variegation in Drosophila?arrow_forwardWhy is it that mutations in bicoid and nanos exhibit genetic maternal effect in Drosophila (a mutation in the maternal parent produces a phenotype that shows up in the offspring), but mutations in runt and gooseberry do not?arrow_forwardA maternal effect gene in Drosophila, called torso, is found as a recessive allele that prevents the correct development of anterior- and posterior-most structures. A wild-type (homozygous) male iscrossed to a female of unknown genotype. This mating produces 100% larva that are missing theiranterior- and posterior-most structures and therefore die during early development. What is the genotype and phenotype of the female fly in this cross? What are the genotypes andphenotypes of the female fly’s parents? Show COMPLETE cross. Maternal genotype:Paternal genotype:F1 genotype:F1 phenotype:arrow_forward
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