Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 43, Problem 14PIAT
Summary Introduction
To explain:
A concept map showing how BTX (batrachotoxin) could kill a mammal through its effects on nervous and muscle tissues.
Introduction:
The BTX is a toxic milky compound that is secreted from the skin of some frog species. It opens the sodium channel and causes membrane depolarization. It kills a mammal by affecting the nervous and muscle tissues.
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α-Bungarotoxin is a powerful neurotoxin found in the venom of a poisonous snake (Bungarus multicinctus). It binds with high specificity to the acetylcholine receptor (AChR; an integral membrane protein) andprevents its ion channel from opening. This interaction was used to purify AChR from the electric organ of torpedo fish.(a) Outline a strategy for using α-bungarotoxin covalently bound to chromatography beads to purify the AChR protein. (b) Outline a strategy for the use of [125I]α-bungarotoxin to purify the AChR protein.
Create at least 6 analogies comparing (3) and contrasting (3) the processes involve in chemical and nervous control in plant animals.
Example:
Photoreceptor (Animal): Phototropism (Plants) (Both involved responding to light stimulus)
You discover a new species of poison-dart frog which secretes a neurotoxin in the skin mucous
with LD50 of 0.5 mg/kg in humans. The toxin causes numbness, paralysis, arrhythmias, cardiac
failure, and death. Based on the patch-clamp record of inward currents when the neurotoxin was
applied to squid axon shown in Figure 2, suggest the mechanism of action of the neurotoxin.
500 PA
5 ms
Figure 2 (Source: Google image)
Chapter 43 Solutions
Biological Science (7th Edition)
Ch. 43 - In a neuron, what creates the electrochemical...Ch. 43 - Prob. 4TYKCh. 43 - Explain the difference between a ligand-gated K+...Ch. 43 - Prob. 6TYUCh. 43 - Prob. 7TYUCh. 43 - Prob. 8TYUCh. 43 - Prob. 9TYPSSCh. 43 - Alzheimer’s disease is a common form of dementia...Ch. 43 - Prob. 11PIATCh. 43 - Prob. 12PIAT
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