Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Textbook Question
Chapter 6, Problem 15P
It has been postulated that the normal (noninfectious) form of prion differs from the infectious form only in secondary/tertiary structure.
a. How might you show that changes in secondary structure occur?
b. If this model is correct, what are the implications for structural prediction schemes?
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The SCAM data for positions V51C and Y96C are different to the other datasets. Describe how the data for these positions are different to the other positions. In each case, explain what the structural basis of these differences may be.
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25) Although the UV280 extinction coefficient of BSA is well known, why was the BCA assay employed to measure protein concentration of the folate labeled BSA? Please provide an explanation. (C) Would the use of reducing agents have an affect on the tertiary structure of BSA—please explain your answer (you will need to investigate the structure of BSA beyond this article)?
. Give two reasons to explain why a proline residue in the middle of an ahelix is predicted to be destabilizing to the helical structure
Chapter 6 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 6 - Prob. 1PCh. 6 - Bovine pancreatic trypsin inhibitor (BPTI; Figure...Ch. 6 - A schematic structure of the subunit of...Ch. 6 - In the protein adenylate kinase, the C-terminal...Ch. 6 - Give two reasons to explain why a proline residue...Ch. 6 - Consider a small protein containing 101 amino acid...Ch. 6 - a. Based on a more conservative answer to Problem...Ch. 6 - The following sequence is part of a globular...Ch. 6 - a. A protein is found to be a tetramer of...Ch. 6 - Under physiological conditions, the protein...
Ch. 6 - Theoretical and experimental measurements show...Ch. 6 - The peptide hormone vasopressin is used in the...Ch. 6 - A protein gives under conditions of buffer...Ch. 6 - A protein gives a single band on SDS get...Ch. 6 - It has been postulated that the normal...Ch. 6 - Below are shown two views of the backbone...Ch. 6 - Do you expect a Pro Gly mutation in a...Ch. 6 - Rank the following in terms of predicted rates...Ch. 6 - Shown below are two cartoon views of the small...Ch. 6 - Prob. 20PCh. 6 - In most cases, mutations in the core of protein...Ch. 6 - A Leu Ala mutation at a site buried the core of...Ch. 6 - Disulfide bonds have been shown to stabilize...Ch. 6 - Cartoon renderings of the proteins Top 7 and adaH2...
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- Novel antiviral agents isolated from Caribbean sponges led to the development of vidarabine, the first nucleoside drug used to treat herpes infections. (a) What monosaccharide and base are present in vidarabine? (b) Draw the structure of cytarabine, an anticancer nucleoside composed of cytosine and the same monosaccharide unit.arrow_forwardIn biochemical and structural terms, how does the cellular form of the prion protein differ from the infectious form? Can you also explain what is the biochemical basis for “infectiousness” of the prion protein?arrow_forwardDraw the structures for nordihydrocapsaicin, capsaicin, and dihydrocapsaicin. How are they structurally related? a. How do their side chain structures differ in terms of carbon chain length and degree of unsaturation? b. What portion of the capsainoid molecular structure contributes the most to its hydrophobicity?arrow_forward
- What structural problems do cross-links "solve" in small domains like the zinc finger and disulfide-containing toxins?arrow_forwardWhat further experiments are needed to provide confidence that the structural data obtained from the SCAM analysis reflects the structure of a properly folded AlaE?arrow_forwardGive two reasons to explain why a proline residue in the middle of an αhelix is predicted to be destabilizing to the helical structure.arrow_forward
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