An explanation corresponding to the fact that in the conversion of His 64 to Ala, the mutant enzyme will cleave substrate B about 1000 times faster than substrate A is to be stated. Concept introduction: The biological catalysts which lower the minimum amount of energy required by the reactants to convert into a product are known as enzymes. An enzyme does not alter the potential energy of reactant and product. Proteolytic enzymes commonly known as proteases are used for the cleavage of protein.

Question

Mutation identity- GLY Outline the effects the mutation of cysteine with GLY on the 3D structure and function of the 3GRS glucathione reducatse protein.

Answer 1

Question

Chapter 9, Problem 2P

Interpretation Introduction

Interpretation:

An explanation corresponding to the fact that in the conversion of His 64 to Ala, the mutant enzyme will cleave substrate B about 1000 times faster than substrate A is to be stated.

Concept introduction:

The biological catalysts which lower the minimum amount of energy required by the reactants to convert into a product are known as enzymes. An enzyme does not alter the potential energy of reactant and product. Proteolytic enzymes commonly known as proteases are used for the cleavage of protein.

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Mutation identity- GLY Outline the effects the mutation of cysteine with GLY on the 3D structure and function of the 3GRS glucathione reducatse protein.

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resting state of the protein, the Lys 216 Schiff base has pKa = 9.5 and Asp 85 has pKa = 3.5. When the conformational change occurs, the proton that was on the Schiff base moves to Asp 85. This should tell you that one or both of these two pKas changed with the conformational change. How does the pKa of Asp 85 compare with the pKa of the Lys 216 Schiff base after the conformational change?