Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 12, Problem 7Q
Summary Introduction
To review:
The biochemical pathway for the conversion ofadipic acid to glucose.
Introduction:
Beta oxidation is a biochemical process in which fatty acid molecules are converted to acetyl CoA (coenzyme A) in the mitochondria. Acetyl CoA enters the Krebs cycle to produce ATP (adenosine triphosphate) molecules. Adipic acid is a dicarboxylic acid, which has industrial importance and is used for the production of nylon. It is also used as a gelling agent. The beta-oxidation product of dicarboxylic acid is succinyl-CoA
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
If acetyl-CoA is labeled with 14C at its methyl group, how many rounds of the cycle are required before 14CO2 is released?
Why is citrate an appropriate inhibitor of phosphofructokinase?
The products of pyrimidine base catabolism, β-alanine and β-aminoisobutyrate, can be further degraded to acetyl-CoA and succinyl-CoA, respectively. Can you suggest the types of reaction required to accomplish these transformations?
Chapter 12 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 12 - Prob. 1QCh. 12 - Prob. 2QCh. 12 - Prob. 3QCh. 12 - Prob. 4QCh. 12 - Prob. 5QCh. 12 - Prob. 6QCh. 12 - Prob. 7QCh. 12 - Prob. 8QCh. 12 - Prob. 9QCh. 12 - Prob. 10Q
Ch. 12 - Prob. 1RQCh. 12 - Prob. 2RQCh. 12 - Prob. 3RQCh. 12 - Prob. 4RQCh. 12 - Prob. 5RQCh. 12 - Prob. 6RQCh. 12 - Prob. 7RQCh. 12 - Prob. 8RQCh. 12 - Prob. 9RQCh. 12 - Prob. 10RQCh. 12 - Prob. 11RQCh. 12 - Prob. 12RQCh. 12 - Prob. 13RQCh. 12 - Prob. 14RQCh. 12 - Prob. 15RQCh. 12 - Prob. 16RQCh. 12 - Prob. 17RQCh. 12 - Prob. 18RQCh. 12 - Prob. 19RQCh. 12 - Prob. 20RQCh. 12 - Prob. 21RQCh. 12 - Prob. 22RQCh. 12 - Prob. 23RQCh. 12 - Prob. 24RQCh. 12 - Prob. 25RQCh. 12 - Prob. 26RQCh. 12 - Prob. 27RQCh. 12 - Prob. 28RQCh. 12 - Prob. 29RQCh. 12 - Prob. 30RQCh. 12 - Prob. 31RQCh. 12 - Prob. 32RQCh. 12 - Prob. 33RQCh. 12 - Prob. 34RQCh. 12 - Prob. 35RQCh. 12 - Prob. 36RQCh. 12 - Prob. 37RQCh. 12 - Prob. 38RQCh. 12 - Prob. 39RQCh. 12 - Prob. 40RQCh. 12 - Prob. 41RQCh. 12 - Prob. 42RQCh. 12 - Prob. 43RQCh. 12 - Prob. 44RQCh. 12 - Prob. 45RQCh. 12 - Prob. 46FBCh. 12 - Prob. 47FBCh. 12 - Prob. 48FBCh. 12 - Prob. 49FBCh. 12 - Prob. 50FBCh. 12 - Prob. 51FBCh. 12 - Prob. 52FBCh. 12 - Prob. 53FBCh. 12 - Prob. 54FBCh. 12 - Prob. 55FBCh. 12 - Prob. 56SACh. 12 - Prob. 57SACh. 12 - Prob. 58SACh. 12 - Prob. 59SACh. 12 - Prob. 60SACh. 12 - Prob. 61TQCh. 12 - Prob. 62TQCh. 12 - Prob. 64TQCh. 12 - Prob. 65TQCh. 12 - Prob. 66TQCh. 12 - Prob. 67TQCh. 12 - Prob. 68TQCh. 12 - Prob. 71TQCh. 12 - Prob. 72TQ
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Based on your knowledge of the structure of NAD+ and an assumption that coenzyme dissociation is the rate limiting step of the alcohol dehydrogenase mechanism, hypothesize why a N249W mutation at the coenzyme binding site would increase the rate of catalysis.arrow_forwardExtending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.arrow_forwardComplete oxidation of a 16-carbon fatty acid can yield 129 molecules of ATP Study Figure 19.2 and determine how many ATP molecules would be generated if a 16-carbon fatly acid were metabolized solely by the TCA cycle, in the form of S acetyl-CoA molecules.arrow_forward
- Considering that triacylglycerols get hydrolyzed in the small intestine because of pancreatic lipases, write the reactions using structural formulas by which a 7-carbon fatty acid is activated and oxidized in the liver of this patient. Indicate cofactors and underscore the final CoA products.arrow_forwardOne of the regulators of the TCA cycle is succinyl CoA. Discuss the rationale for this molecule to be used to regulate the TCA cycle. What is the metabolic role of succinyl CoA?arrow_forwardExplain the chemical change that occurs in converting kynurenine (a product of tryptophan degradation) to kynurenate, a reaction in which α-ketoglutarate is transformed to glutamate.arrow_forward
- A molecule -X inhibits oxidation of stearoyl-CoA by isolated mitochondria but has no effect on palmitoyl-carnitine oxidation, explain.arrow_forwardWhat kind of inhibitor is threo-sphingosine? Explain this type of inhibition.arrow_forwardIf the carbonyl carbon of acetyl-CoA were marked with 14C, where would that carbon be located within oxaloacetate after one turn of the TCA cycle?arrow_forward
- Fourteen NADPH molecules are required to produce one molecules of palmitic acid from acetyl CoA. Substantiate this statement by referring to the enzymatic activities involved in reduction steps during fatty acid synthesis and the number of cycles required to produce palmitic acid from acetyl CoA. How many molecules of ATP is required for the synthesis of palmitic acid from cytosolic acetyl-CoA?arrow_forwardOne of the regulators of the TCA cycle is succinyl CoA. Discuss the rationale for this molecule to be used to regulate the TCA cycle. For what TCA enzymes does succinyl CoA act as an inhibitor?arrow_forwardLooking at the structure of alpha linolenic acid, how many rounds of beta oxidation will occur to fully oxidize the fatty acid into acetyl CoA molecules? Please provide explanationsarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Enzyme Kinetics; Author: MIT OpenCourseWare;https://www.youtube.com/watch?v=FXWZr3mscUo;License: Standard Youtube License