Biology
Biology
12th Edition
ISBN: 9780134813448
Author: Audesirk, Teresa, Gerald, Byers, Bruce E.
Publisher: Pearson,
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Chapter 13, Problem 2AC
Summary Introduction

To explain:

The relation of allele combination in heterozygotes and severity of cystic fibrosis symptoms, with better-functioning allele, with worse-functioning allele, and somewhere in between.

Introduction:

The inherited disease related to the functioning of mucous glands present in various parts of the body is cystic fibrosis. This is a chronic disease affecting major parts of the body and especially lungs. The affected individuals can live only up to thirty years.

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Phenylketonuria (PKU) is an inherited disease caused by a recessive allele. Individuals with PKU have two recessive alleles and have very low levels of an enzyme that is needed to properly break down proteins. If a woman and her husband are both carriers and have three children, what is the probability of each of the following? Show your math. (Hint: You can represent your probabilities as fractions or decimals, but probabilities are always between 0 and 1) a. All three children are of normal phenotype.   b. One or more of the three children have the disease.   c.All three children have the disease.
In humans the allele coding for normal metabolism of the amino acid phenylalanine (P) is dominant   over the recessive autosomal allele (p) that causes the disease phenylketonuria, or PKU.  Without   treatment, this disease is characterized by brain damage due to the failure of the gene to code correctly     for the enzyme phenylalanine hydroxylase.  If a man marries a woman and both are heterozygous for     hemophilia and heterozygous for PKU, what is the chance that they will have a child afflicted by     both diseases? Your response MUST include:(a): list the traits involved (example: Color: Blue- B (dominate) Green - b (recessive) -Do not use this example as this is not part of the problem(b): identify if its a monohybrid or dihybrid cross and why (use prompt above) (c): create a punnet square that represents the problem above
In humans, the genetic disease cystic fibrosis is caused by a recessive allele (a). The normal (healthy) allele is dominant (A). What is the genotype of someone who has cystic fibrosis?   What are the two different genotypes that a healthy person could have?   If two people were both heterozygous for the cystic fibrosis gene, what fraction of their children would be likely to have this disease? Hint: Draw a Punnett square to figure it out.
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