Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 14, Problem 13P
Interpretation Introduction
Interpretation:
Mechanism of growth-hormone signaling should be determined.
Concept introduction:
Growth hormone (GH), also termed as somatotropin, is a peptide hormone that is responsible for the growth, cell regeneration, and reproduction in humans. It is also responsible for stimulating the production of IGF-1, which increases the glucose and the free fatty acids concentrations. It is a mitogen, which has receptors on specific cells.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Diabetes Type 1 and Type 2
Applying signal transduction mechanisms in the context of Type I and Type II Diabetes. Describe the mechanisms by which a cell receives a message and translates it into short-term or long-term effects. Including the role of phosphorylation and feedback inhibition.
Ligand binding and response. The following question involves the ligand binding to a receptor and the receptor's response to that ligand.
What ligand concentration would be required for a full agonist with a KD of 8 nM to achieve a response of 0.75?
MULTIPLE CHOICE
In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not
A. decrease de novo pyrimidine synthesis
B. decrease de novo purine synthesis
C. decrease urate synthesis
D. increase PRPP levels (Phosphoribosyl pyrophosphate)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Process of exocytosis of insulinarrow_forwardActivation of phosphatidylinositol-3-kinase (PI3K) stimulate protein-protein interactions. True or Falsearrow_forward1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Write an expression for the reaction velocity.arrow_forward
- Insulin dependent diabetes is often accompanied by high levels of triacylglycerols in the blood. Suggest a biochemical explanation.arrow_forwardQuestion:- Explain why it makes sense for the PDH complex in liver to be active when dephosphorylated.arrow_forwardTrue or False : When the inhibitory Ga (Gia) protein is mutated and increases its intrinsic GTPase activity, adenylate cyclase becomes more active and Gia becomes more active.arrow_forward
- In muscle cells, when adrenaline binds to beta-adrenergic receptor, it trigger signaling cascade leading to active glycogen phosphorylate breaks up glycogen into glucose subunits (Glycogen -> G1P). Base on following figure, describe this signaling cascade:arrow_forwardProtein Phosphatase 1: What overall effect does PP1 have on the storage or breakdown of glycogen? (1 point) How does PPI regulate the activity of its targets? (1 point) Which enzymes are its targets? (2 points) What activates it [hormone (pathway activator) and enzyme (immediate activator)]? (2 points) Hormone: Enzyme:arrow_forwardQUESTION:- Using specific examples, discuss the versatility of different subtypes of GPCRs for the hormone epinephrine.arrow_forward
- 29. Synthesis signal. How does insulin stimulate glycogen synthesis?arrow_forwardDiabetes often results in the production of reduced levels of insulin. Researchers claim that a drug that binds to and blocks the active site of GSK3 might mimic the role of insulin in the pathway shown in Figure 2. Provide reasoning to justify the researchers' claim.arrow_forwardKetosis in Dairy Cattle: 1. Explain why propionate can contribute to the next synthesis of glucose but acetic acid cant.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning