Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 14, Problem 33P
Suppose that you could obtain radioactively labeled penicillin. How could you use this compound to distinguish whether a penicillin-resistant bacterium harbors a gene encoding penicillinase or whether the bacterium has acquired a mutation in penA, penB, or mtr?
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Suppose that you could obtain radioactively labeledpenicillin. How could you use this compound to distinguish whether a penicillin-resistant bacterium harborsa gene encoding penicillinase or whether the bacteriumhas acquired a mutation in penA, penB, or mtr?
Suppose that you could obtain radioactively labeledpenicillin. How could you use this compound to distinguish whether a penicillin-resistant bacterium harborsa gene encoding penicillinase or whether the bacteriumhas acquired a mutation in penB, or mtr?
Suppose that E. coli sustains a mutation in its gene for the lac operon repressor such that the repressor is ineffective. What effect would this have on the bacterium’s ability to catabolize lactose? Would the mutant strain have an advantage over wild-type cells? Explain your answer.
Chapter 14 Solutions
Genetics: From Genes to Genomes
Ch. 14 - Choose the phrase from the right column that best...Ch. 14 - The unicellular, rod-shaped bacterium E. coli is 2...Ch. 14 - Now that the sequence of the entire E. coli K12...Ch. 14 - Bacterial genomes such as that of E. coli...Ch. 14 - List at least three features of eukaryotic genomes...Ch. 14 - Describe a mechanism by which a gene could move...Ch. 14 - High salt concentrations tend to cause protein...Ch. 14 - Recently, scientists tested the possibility that...Ch. 14 - A recent metagenomic study analyzed the...Ch. 14 - Linezolid is a new type of antibiotic that...
Ch. 14 - A liquid culture of E. coli at a concentration of...Ch. 14 - Pick out the medium i, ii, iii, or iv onto which...Ch. 14 - This problem concerns Fig. 14.14, which...Ch. 14 - In two isolates one is resistant to ampicillin,...Ch. 14 - E. coli cells usually have only one copy of the F...Ch. 14 - In E. coli, the genes purC and pyrB are located...Ch. 14 - DNA sequencing of the entire H. influenzae genome...Ch. 14 - Genes encoding toxins are often located on...Ch. 14 - a. You want to perform an interrupted-mating...Ch. 14 - In Problem 19, do you think that most of the...Ch. 14 - One issue with interrupted-mating experiments such...Ch. 14 - Prob. 22PCh. 14 - Starting with an F- strain that was prototrophic...Ch. 14 - You can carry out matings between an Hfr and F...Ch. 14 - Genome sequences show that some pathogenic...Ch. 14 - Generalized and specialized transduction both...Ch. 14 - This problem highlights some useful variations of...Ch. 14 - A researcher has a Trp auxotrophic strain of E....Ch. 14 - Streptococcus parasanguis is a bacterial species...Ch. 14 - The sequence at one end of one strand of the...Ch. 14 - Scientists who study amino acid biosynthesis...Ch. 14 - Suppose that you could obtain radioactively...Ch. 14 - Prob. 34PCh. 14 - Some scientists are trying to engineer...
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- Suppose that E. coli sustains a mutation in its gene for the lac operon repressor making the repressor ineffective . How would this mutation affect the bacterium's ability to catabolize lactose? Would the mutant strain have an advantage over the wild-type strain? Explain your answer.arrow_forwardSuppose that the E. coli gene for the lac operon repressor has a mutation that makes the repressor ineffective. What effect would this have on the bacterium’s ability to catabolize lactose? Would the mutant strain have an advantage over wild-type cells? Explain your answerarrow_forwardSuppose that E. coli sustains a mutation in its gene for the lac operon depressor making the repressive ineffective. How would this mutation affect the bacterium's ability to catabolize lactose? Would the mute to strain have an advantage over the wild-type strain?arrow_forward
- Suppose that E. coli sustains a mutation in its gene for the lac operon repressor making the repressor ineffective. How would this mutation affect the bacterium's ability to catabolize lactose?arrow_forwardhorizontal gene transfer Explain why the rapid acquisition of antibiotic resistance by bacterial pathogens is associated with growth in biofilms or growth in the presence of bacteriophages.arrow_forwardWhat would happen to the ability of bacteriophage λ tolyse a host cell if it acquired a mutation in the OR bindingsite for the Cro protein? Why?arrow_forward
- Given the following genotypes, explain, by answering the questions in each number, how the mutation (identified by a (-) superscript) will affect E. coli grown in lactose medium. Will there be a complete set ofgene products? (Yes/No) Will the lac operon be turnedon/off? Will the cell survive? (Yes/No) a. i + p + o + z - y + b. i + p - o + z + y + c. i + p + o - z + y +arrow_forwardWhy can it be said that transcription of thebacteriophage T7 genome requires two enzymes?arrow_forwardSuppose that one species of bacteria obtained one gene encoding a restriction endonuclease by horizontal gene transfer. Would you expect this acquisition to be beneficial?arrow_forward
- In the Meselson experiment, would it have been possible to utilize N14 in the original bacteria and only allow growing bacteria to access N15 to build new (F1) bacteria and get the same results? Explain why. (I need an answer in full complete sentences with the question restated in the response.)arrow_forwardIn Hershey-Chase experiment, bacteriophages protein coats were tagged with radioactive isotope S-32. These phages were used to infect E. coli cells and the cells were further centrifuged to form pellets. Why was the radioactivity level of S-32 found greater outside the cells compared to the E. coli cell pellets? Explain briefly. If the experiment is repeated in the same manner but this time the phage protein coats are labelled with isotope X and the phage DNA with isotope Y, which isotope’s radioactivity will be found in greater amounts in the E. coli cell pellets after centrifugation? Explain briefly.arrow_forwardAn individual carries a somatic mutation that changes a lysinecodon into a glutamic acid codon. Prior to acquiring this mutation,the individual had been exposed to UV light, proflavin, and5-bromouracil. Which of these three agents would be the mostlikely to have caused this somatic mutation? Explain your answer.arrow_forward
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