Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 15, Problem 25RQ
Summary Introduction

To review:

The number of ATP molecules (adenosine triphosphate) generated when NADH (reduced nicotinamide adenine dinucleotide) is oxidized in the mitochondria, and the net ATP requirement for urea synthesis.

Introduction:

In the mitochondria, all the ammonia molecules come together with the respiration byproduct carbon dioxide to form carbamoyl phosphate, which enters the urea cycle. The urea cycle requires energy in the form of ATP, and hence, is energetically expensive, but it occurs anyway in the body because it is necessary to eliminate toxic products from the body.

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Question 1: The overall process enabled by the glyoxylate cycle is: (2acetyl-CoA) + (NAD+) + (2H2O) → (succinate) + (2CoA) + (NADH) + (2H+) Dissect this process further by writing down all of the reactions that are actually involved in making one succinate from two acetyl-CoA units. Show chemical structure for all intermediates.

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Biochemistry: The Molecular Basis of Life

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