Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 15, Problem 36RQ
Summary Introduction
To review:
The activation of the urea cycle after a high protein meal.
Introduction:
Urea cycle is the process of producing urea by certain biochemical reactions. It is also known as the ornithine cycle. It was discovered by HansKrebs and KurtHenseleit. Thus, it is also called as KrebsHenseleit cycle or Krebs urea cycle. It involves the conversion of highly toxic ammonia into urea, which is later excreted from the body. It occurs primarily in the liver.
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Please expound your answer. If you'll write, please do it legibly and clearly. Thank you. Explain the significance of Wohler’s synthesis of urea in his lab.
If aspartate is labeled with deuterium D (= H-2 = 12H), answer questions a-c to determine where the label will end up in oxaloacetate after the involvement of aspartate in the urea cycle.
Citrullene is a special amino acid that is used in the urea cycle and as a precursor for synthesis of the aminoacid Arg in the body. In which category would you place citrullene? Explain.
Chapter 15 Solutions
Biochemistry: The Molecular Basis of Life
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- Urea is a metabolic by-product of the catabolism of _____________.arrow_forwardName the enzyme whose substrate is(a) Urea (b) Cellulosearrow_forwardThe enzyme carbamoyl phosphate synthetase is activated when the glutamate concentration decreases, which in turn activates the urea cycle. True Or Falsearrow_forward
- Where does aspartate enter the urea cycle and what compound does it eventually leave as? What metabolic cycle does this compound then enter?arrow_forwardIf aspartate is labeled with deuterium D (= H-2 = 12H), answer questions a-c to determine where the label will end up in oxaloacetate after the involvement of aspartate in the urea cycle. Where does the label end up in arginosuccinate? Where is the label in fumarate? Where is the label in oxaloacetate?arrow_forwardtrue/false: N-acetyl glutamate regulates the urea cycle by increasing the transcription of the enzymes involved.arrow_forward
- The amino acids glutamine and glutamate are central toamino acid metabolism. Explain.arrow_forwardWhat form of activated glucose is used in the biosynthesis ofglycogen by bacteria?arrow_forwardIncluding the carbamoyl phosphate synthetase step (CPS I) and the four steps of the urea cycle, how many ATP equivalents (phosphoanhydride bonds) are utilized to drive the formation of one urea molecule?arrow_forward
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