Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 18, Problem 13PDQ
RNAi may be directed by small interfering RNAs (siRNAs) or microRNAs (miRNAs); how are these similar, and how are they different?
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Give a brief description of how RNAi works in cells specifying the molecules involved?
What is the difference between an miRNA and an siRNA. How dothese ncRNAs affect mRNAs?
What is the origin of small interfering RNAs, microRNAs, and Piwi-interacting RNAs? What do these RNA molecules do in the cell?
Chapter 18 Solutions
Concepts of Genetics (12th Edition)
Ch. 18 - Some mutations in the tra gene of Drosophila cause...Ch. 18 - Some scientists use the analogy that the...Ch. 18 - Consider the example that actin mRNA localization...Ch. 18 - What is alternative splicing, where does it occur,...Ch. 18 - What role might the expanded tri- and...Ch. 18 - DM1 is characterized by a phenomenon known as...Ch. 18 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 18 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 18 - List three types of alternative splicing patterns...Ch. 18 - Consider the CT/CGRP example of alternative...
Ch. 18 - Explain how the use of alternative promoters and...Ch. 18 - Explain how a tissue-specific RNA-binding protein...Ch. 18 - The regulation of mRNA decay relies heavily upon...Ch. 18 - Nonsense-mediated decay is an mRNA surveillance...Ch. 18 - AU-rich elements (AREs) are cis-elements in mRNAs...Ch. 18 - What are processing bodies (P bodies), and what...Ch. 18 - In 1998, future Nobel laureates Andrew Fire and...Ch. 18 - Present an overview of RNA interference (RNAi)....Ch. 18 - RNAi may be directed by small interfering RNAs...Ch. 18 - Prob. 14PDQCh. 18 - In principle, RNAi may be used to fight viral...Ch. 18 - Prob. 16PDQCh. 18 - Prob. 17PDQCh. 18 - Prob. 18PDQCh. 18 - Prob. 19PDQCh. 18 - How is it possible that a given mRNA in a cell is...Ch. 18 - Prob. 21PDQCh. 18 - Prob. 22PDQCh. 18 - Prob. 23PDQCh. 18 - Prob. 24ESPCh. 18 - Prob. 25ESPCh. 18 - Mutations in the low-density lipoprotein receptor...Ch. 18 - RNA helicases are a class of proteins that bind...Ch. 18 - While miRNA response elements (MREs) may be...Ch. 18 - RNAi is currently being tested as a therapeutic...Ch. 18 - The localization and translational control of...Ch. 18 - Explain how the expression of a single gene can be...
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- A double-stranded RNA has been generated by release/splicing out of an intron within the nucleus...outline the pathway taken to generate microRNA and its action on the shutdown of protein biosynthesisarrow_forwardWhat is single guide RNA (sgRNA) ?arrow_forwardAre the remaining 98% of human DNA are non-coding RNAs (ncRNAs: sncRNA and lncRNA) which are extensively transcribed and participate in the regulation of protein-coding genes by forming complex regulatory networks?arrow_forward
- Some eukaryotic mRNAs contain an AU-rich element in the 3’ untranslated region. What would be the effect on gene regulation by a microRNA (miRNA) if the AU-rich element was mutated or deleted?arrow_forwardExplain the piRNAs (piwi-interacting RNAs) ? How are they used ?arrow_forwardWhat are the principal similarities and differences between the processes of RNA interference by short interfering RNAs and silencing by micro RNAs?arrow_forward
- Do you think it would be easier to mutate the GR receptor or treat someone with a miRNA to overcome the negative aspects of the stress response? Why?arrow_forwardList two different ways in which trans-acting small RNAs(sRNAs) regulate the expression of target genes.arrow_forwardWhat is RNA modification? Explain with the help of diagramsarrow_forward
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