Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 18, Problem 2NST
Some scientists use the analogy that the RNA-induced silencing complex (RISC) is a “programmable search engine” that uses miRNAs as programs. What does RISC search for, and how does an miRNA “program” the search? What does RISC do when it finds what it is searching for?
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Chapter 18 Solutions
Concepts of Genetics (12th Edition)
Ch. 18 - Some mutations in the tra gene of Drosophila cause...Ch. 18 - Some scientists use the analogy that the...Ch. 18 - Consider the example that actin mRNA localization...Ch. 18 - What is alternative splicing, where does it occur,...Ch. 18 - What role might the expanded tri- and...Ch. 18 - DM1 is characterized by a phenomenon known as...Ch. 18 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 18 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 18 - List three types of alternative splicing patterns...Ch. 18 - Consider the CT/CGRP example of alternative...
Ch. 18 - Explain how the use of alternative promoters and...Ch. 18 - Explain how a tissue-specific RNA-binding protein...Ch. 18 - The regulation of mRNA decay relies heavily upon...Ch. 18 - Nonsense-mediated decay is an mRNA surveillance...Ch. 18 - AU-rich elements (AREs) are cis-elements in mRNAs...Ch. 18 - What are processing bodies (P bodies), and what...Ch. 18 - In 1998, future Nobel laureates Andrew Fire and...Ch. 18 - Present an overview of RNA interference (RNAi)....Ch. 18 - RNAi may be directed by small interfering RNAs...Ch. 18 - Prob. 14PDQCh. 18 - In principle, RNAi may be used to fight viral...Ch. 18 - Prob. 16PDQCh. 18 - Prob. 17PDQCh. 18 - Prob. 18PDQCh. 18 - Prob. 19PDQCh. 18 - How is it possible that a given mRNA in a cell is...Ch. 18 - Prob. 21PDQCh. 18 - Prob. 22PDQCh. 18 - Prob. 23PDQCh. 18 - Prob. 24ESPCh. 18 - Prob. 25ESPCh. 18 - Mutations in the low-density lipoprotein receptor...Ch. 18 - RNA helicases are a class of proteins that bind...Ch. 18 - While miRNA response elements (MREs) may be...Ch. 18 - RNAi is currently being tested as a therapeutic...Ch. 18 - The localization and translational control of...Ch. 18 - Explain how the expression of a single gene can be...
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- What is miRNA replacement therapy? Describe three examples of this treatment approach.arrow_forwardDo you think it would be easier to mutate the GR receptor or treat someone with a miRNA to overcome the negative aspects of the stress response? Why?arrow_forwardWhich of the following is NOT true of miRNAs? A. Pri-miRNAs are processed by Drosha in the nucleus to form pre-miRNAs which are cleaved by dicer in the cytoplasm to generate a miRNA. B. miRNAs always lead to the degradation of their mRNA targets. C. miRNAs can be encoded within the vertebrate genome within introns and within intergenic regions. D. miRNAs can generally target more than one mRNAarrow_forward
- Let’s suppose that the overexpression of a particular miRNA was associatedwith pancreatic cancer. Which of the following agents might be effective in treating this type of cancer?a. Enoxacinb. A DNA demethylating agentc. An anti-miRNA oligonucleotided. Both a and barrow_forwardWhat is the main difference between Sirna and miRNA?arrow_forwardwhich enzyme is used in the processing of miRNAs that are encoded in the genome but not in the processing of exogenously added siRNAs?arrow_forward
- Compare and contrast the origins and functions of miRNA and siRNAarrow_forwardmiRNA molecules act as specificity factors, which direct effector proteins to target ______ molecules via base-pairing. A. RNA B. Carbohydrate C. Lipid D. DNA E. Proteinarrow_forwardWhat is the difference between miRNA and siRNA?arrow_forward
- The number of microRNAs encoded by the genome varies widely among organisms: some species have many miRNA genes and other species have relatively few. Researchers have determined the number of miRNA genes possessed by different species and have made the following observations: a. The number of miRNA genes found on a chromosome is not correlated with chromosome length. In other words, longer chromosomes do not necessarily have more miRNA genes. b. Most species show a strong positive correlation between the number of miRNA genes on a chromosome and the number of non-proteinencoding genes on that chromosome. In other words, chromosomes with more non-protein-encoding genes have more miRNA genes. c. Many species display a strong positive correlation between the number of miRNA genes on a chromosome and the number of protein encoding genes on that chromosome. In other words, chromosomes with more protein-encoding genes have more miRNA genes Propose possible explanations for these…arrow_forwardThe number of microRNAs encoded by the genome varies widely among organisms: some species have many miRNA genes and other species have relatively few. Researchers have determined the number of miRNA genes possessed by different species and have made the following observations: a. The number of miRNA genes found on a chromosome is not correlated with chromosome length. In other words, longer chromosomes do not necessarily have more miRNA genes. b. Most species show a strong positive correlation between the number of miRNA genes on a chromosome and the number of non-proteinencoding genes on that chromosome. In other words, chromosomes with more non-protein-encoding genes have more miRNA genes. c. Many species display a strong positive correlation between the number of miRNA genes on a chromosome and the number of proteinencoding genes on that chromosome. In other words, chromosomes with more protein-encoding genes have more miRNA genes. Propose possible explanations for these…arrow_forwardThe number of microRNAs encoded by the genome varies widely among organisms: some species have many miRNA genes and other species have relatively few. Researchers have determined the number of miRNA genes possessed by different species and have made the following observations: Q. The number of miRNA genes found on a chromosome is not correlated with chromosome length. In other words, longer chromosomes do not necessarily have more miRNA genes.arrow_forward
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