Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 18, Problem 2PDQ
CONCEPT QUESTION Review the Chapter Concepts list on page XXX. The third concept describes how the interaction between cis-acting sequence elements on mRNA and trans-acting RNA-binding proteins (RBPs) regulates mRNAs and gene expression. Write a short essay describing how an mRNA may be regulated in three different ways by specific cis-elements and RBPs.
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Chapter 18 Solutions
Concepts of Genetics (12th Edition)
Ch. 18 - Some mutations in the tra gene of Drosophila cause...Ch. 18 - Some scientists use the analogy that the...Ch. 18 - Consider the example that actin mRNA localization...Ch. 18 - What is alternative splicing, where does it occur,...Ch. 18 - What role might the expanded tri- and...Ch. 18 - DM1 is characterized by a phenomenon known as...Ch. 18 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 18 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 18 - List three types of alternative splicing patterns...Ch. 18 - Consider the CT/CGRP example of alternative...
Ch. 18 - Explain how the use of alternative promoters and...Ch. 18 - Explain how a tissue-specific RNA-binding protein...Ch. 18 - The regulation of mRNA decay relies heavily upon...Ch. 18 - Nonsense-mediated decay is an mRNA surveillance...Ch. 18 - AU-rich elements (AREs) are cis-elements in mRNAs...Ch. 18 - What are processing bodies (P bodies), and what...Ch. 18 - In 1998, future Nobel laureates Andrew Fire and...Ch. 18 - Present an overview of RNA interference (RNAi)....Ch. 18 - RNAi may be directed by small interfering RNAs...Ch. 18 - Prob. 14PDQCh. 18 - In principle, RNAi may be used to fight viral...Ch. 18 - Prob. 16PDQCh. 18 - Prob. 17PDQCh. 18 - Prob. 18PDQCh. 18 - Prob. 19PDQCh. 18 - How is it possible that a given mRNA in a cell is...Ch. 18 - Prob. 21PDQCh. 18 - Prob. 22PDQCh. 18 - Prob. 23PDQCh. 18 - Prob. 24ESPCh. 18 - Prob. 25ESPCh. 18 - Mutations in the low-density lipoprotein receptor...Ch. 18 - RNA helicases are a class of proteins that bind...Ch. 18 - While miRNA response elements (MREs) may be...Ch. 18 - RNAi is currently being tested as a therapeutic...Ch. 18 - The localization and translational control of...Ch. 18 - Explain how the expression of a single gene can be...
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- Compare bacterial and eukaryotic mRNAs, and explain the functional significance of their structural differences.arrow_forwardThe pre-mRNA transcript and protein made by several mutant genes were examined. The results are given below. Determine where in the gene a likely mutation lies: the promoter region, exon, intron, cap on mRNA, or ribosome binding site. a. normal-length transcript, normal-length nonfunctional protein b. normal-length transcript, no protein made c. normal-length transcript, normal-length mRNA, short nonfunctional protein d. normal-length transcript, longer mRNA, shorter nonfunctional protein e. transcript never madearrow_forwardBriefly discuss (referring to the images provided) why mutant 2 fails to produce functional protein. Note that none of the mRNA transcribed from this gene is of the expected size; some of the mRNA molecules produced are 223 nucleotides shorter than expected, whilst others are 47 nucleotides longer than expected.arrow_forward
- In eukaryotes there is not a consistent relationship between the length of the coding sequence of a gene and the length of the mature mRNA it encodes, even though one nucleotide in DNA = one nucleotide in pre-mRNA or primary transcript. Explain why this is so.arrow_forwardYou are investigating the expression of the dKB gene in the eukaryotic species. dKB mRNA in lung cells but not in liver cells. -For each cell type, lung and liver, indicate whether the dKB gene is present or absent. Describe what might be occurring at the molecular level that would explain the observed difference in gene expression between lung and liver cells.arrow_forwardDiscuss the advantages, in terms of protein structure and evolution, that result from alternative mRNA splicing.arrow_forward
- Answer these questions concerning promoters. a) What role do promoters play in transcription? b) What is the common structure of bacterial promoter with respect to consensus sequences? c) Eukaryotic promoters are more variable than bacterial promoters. Why? d) What is the meaning of the term alternative promoter? How does the use of alternative promoters affect transcription?arrow_forwardConsider the following mRNA base sequence 5' CUG-CAC 3' (a) What dipeptide is coded for by this mRNA? (b) What dipeptide is formed if a mutation converts CUG to CUU? (c) What dipeptide is formed if a mutation converts CAC to CGC? (d) What dipeptide is formed if a mutation converts CUG to CUU and CAC to CGC?arrow_forwardDescribe some of the ways in which mRNAs might regulate gene expression. What is the role of poly(A) in mRNA stability? How might the cell regulate the stability Different mRNAs?arrow_forward
- Name the three main stages of pre-mRNA processing. Explain the importance of each of the stages of pre-mRNA processing.arrow_forwardA membrane-associated protein kinase has the sequence -GMCLVS at its C-terminus, which has been shown by mutagenesis to be essential for its biological function and sub cellular location.a) What is the most likely post-translational modification that this motif would be susceptible to?b) How is this modification introduced to the protein?c) What is the likely effect of this modification on the behaviour of the protein?d) What other modification to N-terminus of the protein might achieve a similar effect on the behaviour of the protein?arrow_forwardHey, I need help with this: Describe the main events that occur after transcription to generate a mature mRNA and ensure its correct localisation in the cell. Please include splicing, 5' and 3' modifications, RNA export from the nucleus, and how some mRNAs are localised within the cytoplasm. Please be very detailed and long explanation ,and dont copy from google answer in your own words asap pleasearrow_forward
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