7 ln pharmaceutical research, structural analogs (or derivatives) of drugs are often made in order to see if they have similar biological properties. Following is a structural analog of Peramivir (Problem 19-46) called A. (a) Complete the drawings of the alternative chair conformations of A, making sure to note the numbering of the ring atoms. Which of the alternative chair conformations is more stable? (Chapter 1 1) (b) A is formed from the cyclization of B. Which two functional groups in B react to form A? What is the name of the new functional group formed when these two groups react to close the ring?

BuyFind

Introduction to General, Organic a...

11th Edition
Frederick A. Bettelheim + 4 others
Publisher: Cengage Learning
ISBN: 9781285869759
BuyFind

Introduction to General, Organic a...

11th Edition
Frederick A. Bettelheim + 4 others
Publisher: Cengage Learning
ISBN: 9781285869759

Solutions

Chapter 19, Problem 19.47P
Textbook Problem

7 ln pharmaceutical research, structural analogs (or derivatives) of drugs are often made in order to see if they have similar biological properties. Following is a structural analog of Peramivir (Problem 19-46) called A.

Chapter 19, Problem 19.47P, 7 ln pharmaceutical research, structural analogs (or derivatives) of drugs are often made in order , example  1

(a) Complete the drawings of the alternative chair conformations of A, making sure to note the numbering of the ring atoms. Which of the alternative chair conformations is more stable? (Chapter 1 1)

Chapter 19, Problem 19.47P, 7 ln pharmaceutical research, structural analogs (or derivatives) of drugs are often made in order , example  2

(b) A is formed from the cyclization of B. Which two functional groups in B react to form A? What is the name of the new functional group formed when these two groups react to close the ring?

Chapter 19, Problem 19.47P, 7 ln pharmaceutical research, structural analogs (or derivatives) of drugs are often made in order , example  3

Expert Solution

Want to see the full answer?

Check out a sample textbook solution.

Want to see this answer and more?

Experts are waiting 24/7 to provide step-by-step solutions in as fast as 30 minutes!*

*Response times vary by subject and question complexity. Median response time is 34 minutes and may be longer for new subjects.

Chapter 19 Solutions

Introduction to General, Organic and Biochemistry
Ch. 19 - 1 The analgesic phenacetin is synthesized by...Ch. 19 - 2 Phenobarbital is a long-acting sedative,...Ch. 19 - 3 Following is a structural formula for aspartame,...Ch. 19 - 4 Why are nylon-66 and Kevlar referred to as...Ch. 19 - 5 Draw short sections of two parallel chains of...Ch. 19 - 6 Why are Dacron and Mylar referred to as...Ch. 19 - 7 What type of structural feature do the...Ch. 19 - 8 Draw structural formulas for the mono-, di-, and...Ch. 19 - 9 1 ,3-Dihydroxy-2-propanone (dihydroxyacetone)...Ch. 19 - 0 Show how triphosphoric acid can form from three...Ch. 19 - 1 Write an equation for the hydrolysis of...Ch. 19 - 2 (Chemical Connections 19A) Locate the ester...Ch. 19 - 3 (Chemical Connections 19A) What structural...Ch. 19 - 4 (Chemical Connections 19A) A commercial Clothing...Ch. 19 - 5 (Chemical Connections 19B) (a) Identify the...Ch. 19 - 6 (Chemical Connections 19C) What is the compound...Ch. 19 - 7 (Chemical Connections 19C) Name the two...Ch. 19 - 8 (Chemical Connections 19C) Once it has been...Ch. 19 - 9 (Chemical Connections 19C) What is the...Ch. 19 - 0 (Chemical Connections 19D) What is the...Ch. 19 - 1 (Chemical Connections 19D) How do sunscreens...Ch. 19 - 2 (Chemical Connections 19D) What structural...Ch. 19 - (Chemical Connections 19E) Barbiturates are...Ch. 19 - 4 (Chemical Connections 19F) Why do Lactomer...Ch. 19 - 5 Benzocaine, a topical anesthetic, is prepared by...Ch. 19 - 6 The analgesic acetaminophen is synthesized by...Ch. 19 - 7 1,3-Diphosphoglycerate, an intermediate in...Ch. 19 - 8 In Chapter 22, we will discuss a class of...Ch. 19 - 9 We have seen that an amide can be formed from a...Ch. 19 - 0 We will encounter the following molecule in our...Ch. 19 - 1 Starting with ethylene as the only source of...Ch. 19 - 2 From what carboxylic acid and amine or ammonia...Ch. 19 - 3 N,N-Diethyl m-toluamide (DEET) is the active...Ch. 19 - 4 Following are structural formulas for two local...Ch. 19 - 5 Barbiturates are prepared by treating diethyl...Ch. 19 - 6 Consider the experimental antiviral drug...Ch. 19 - 7 ln pharmaceutical research, structural analogs...Ch. 19 - 8 Following is an example of how a moth uses a...Ch. 19 - 9 Only certain types of polymers are readily...

Additional Science Textbook Solutions

Find more solutions based on key concepts
What are the two major divisions of natural science?

An Introduction to Physical Science

Which of the following is not one of the ways fats are useful in foods? Fats contribute to the taste and smell ...

Nutrition: Concepts and Controversies - Standalone book (MindTap Course List)

What are genomes?

Human Heredity: Principles and Issues (MindTap Course List)

In a dietary context, how do HDL and LDL differ in function?

General, Organic, and Biological Chemistry

A guitars steel string vibrates (see Fig. 30.5). The component of magnetic field perpendicular to the area of a...

Physics for Scientists and Engineers, Technology Update (No access codes included)