Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 19, Problem 39RQ
Summary Introduction

To review:

The deoxyribonucleic acid (DNA) sequence that could code for peptide: Ala-Ser-Phe-Tyr-Ser-Lys-Lys-Leu-Ala-Asp-Val-Ile

Introduction:

The actual information that a peptide contains is derived from the DNA sequence. DNA sequences are converted to ribonucleic acid (RNA)sequencesduring transcription. RNA sequences are usedto encode amino acids, whichfurther form peptides.

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Lactose permease, a protein of E. coli, is composed of a singlepolypeptide that is 417 amino acids in length. By convention, theamino acids within a polypeptide are numbered from the aminoterminalend to the carboxyl-terminal end. Are the following questionsabout lactose permease true or false?A. Because the sixty-fourth amino acid is glycine and the sixty- eighth amino acid is aspartic acid, the codon for glycine,64, is closer to the 3′ end of the mRNA than the codon for aspartic acid, 68.B. The mRNA that encodes lactose permease must be greater than1241 nucleotides in length.
What are the medical/ therapeutic applications of the nucleotide sleectivity?
What useful information might you get if you did determine the Nterminal amino acid as a separate step?

Chapter 19 Solutions

Biochemistry: The Molecular Basis of Life

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