The preparation of haloperidol compound has to be proposed. Concept Introduction: Retrosynthetic analysis: In an organic synthesis , the transformation of target molecule into simpler precursor molecules regardless of any reactivity or interaction with reagents. A retrosynthetic analysis is involving the breaking of a bond to form two or more synthons.

Question

The shrub ma huang (Section 5.4A) contains two biologically activestereoisomers—ephedrine and pseudoephedrine—with two stereogeniccenters as shown in the given structure. Ephedrine is one component ofa once-popular combination drug used by body builders to increaseenergy and alertness, whereas pseudoephedrine is a nasaldecongestant.a.) Draw the structure of naturally occurring (−)-ephedrine, which has the1R,2S configuration.b.) Draw the structure of naturally occurring (+)-pseudoephedrine, whichhas the 1S,2S configuration.c.) How are ephedrine and pseudoephedrine related?d.) Draw all other stereoisomers of (−)-ephedrine and (+) pseudoephedrine, and give the R,S designation for all stereogeniccenters.e.) How is each compound drawn in part (d) related to (−)-ephedrine?

Answer 1

Question

Chapter 22, Problem 22.61P

(a)

Interpretation Introduction

Interpretation:

The preparation of haloperidol compound has to be proposed.

Concept Introduction:

Retrosynthetic analysis:

In an organic synthesis, the transformation of target molecule into simpler precursor molecules regardless of any reactivity or interaction with reagents. A retrosynthetic analysis is involving the breaking of a bond to form two or more synthons.

(b)

Interpretation Introduction

Interpretation:

The chirality of haloperidol, and the possible of number of isomers in the given synthesis has to be given.

Concept Introduction:

Stereoisomers and chiral:

Isomers differing only in their spatial arrangement of atoms are called as stereoisomers.

The geometric property of a molecule that cannot be superimposed on its mirror image is known as chirality. Chiral carbon is the one which is attached with four different groups or atoms.

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