Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 22, Problem 29P
Suppose a GWAS investigation found a particular LD block to be associated with people’s preference for chocolate or vanilla ice cream. How could you identify the specific gene within this region of the genome whose alleles help determine this preference?
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Chapter 22 Solutions
Genetics: From Genes to Genomes
Ch. 22 - Choose the best matching phrase in the right...Ch. 22 - Suppose you grew genetically identical dandelion...Ch. 22 - How can each of the following be used in...Ch. 22 - Two different groups of scientists studying a rare...Ch. 22 - Which of the following statements would be true of...Ch. 22 - Studies have indicated that for pairs of twins...Ch. 22 - Prob. 7PCh. 22 - Prob. 8PCh. 22 - Table 22.2 lists concordance values for MZ and DZ...Ch. 22 - Prob. 10P
Ch. 22 - Prob. 11PCh. 22 - Two alleles at one locus produce three distinct...Ch. 22 - In a certain plant, leaf size is determined by...Ch. 22 - Compare and contrast the use of SNP genotyping: i...Ch. 22 - Explain the similarities and differences between...Ch. 22 - In Fig. 22.14c, the fw2.2 causal gene was...Ch. 22 - Among the most prevalent pathologies that afflict...Ch. 22 - Human geneticists have found the Finnish...Ch. 22 - Canavan disease, caused by homozygosity for a...Ch. 22 - In GWAS analysis, because of the existence of LD...Ch. 22 - In Fig. 22.15: a. Why do some chromosomes in the...Ch. 22 - Consider the triangle diagram shown in Fig. 22.17....Ch. 22 - Prob. 23PCh. 22 - You conduct a Case/Control study comparing the...Ch. 22 - Prob. 25PCh. 22 - ALS amyotrophic lateral sclerosis is a rare, fatal...Ch. 22 - Through GWAS explorations, scientists have...Ch. 22 - In domesticated dogs, size has a high...Ch. 22 - Suppose a GWAS investigation found a particular LD...Ch. 22 - In 2008, Time magazine named as its invention of...
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- Recently, scientists have identified a mutation that is found at high frequency in Finnish populations, located in northern Europe where the winter is very cold. This mutation is believed to be a “cold sensitive” allele that warns people of extreme cold temperatures. Could this allele have undergone a “selective sweep”, if it had suddenly appeared in this northern population of humans? How would such a selective sweep be detected with genome data?arrow_forwardTraditional gene mapping has been applied successfully to a variety of organisms including yeast, fungi, maize, and Drosophila. However, human gene mapping has only recently shared a similar spotlight. What factors have delayed the application of traditional gene-mapping techniques in humans?arrow_forwarddescribe two blotting methods (i.e., Northern blottingand Western blotting) used to detect gene products. Northern blotting detects RNA and Western blotting detects proteins. Supposethat a female fruit fly is heterozygous for a maternal effect gene,which we will call gene B. The female is Bb. The normal allele, B,encodes a functional mRNA that is 550 nucleotides long. A recessive allele, b, encodes a shorter mRNA that is 375 nucleotideslong. (Allele b is due to a deletion within this gene.) How couldyou use one or more of these techniques to show that nurse cellstransfer gene products from gene B to developing oocytes? Youmay assume that you can dissect the ovaries of fruit flies and isolate oocytes separately from nurse cells. In your answer, describeyour expected results.arrow_forward
- Hi, would you plaase answer this question? In a study conducted by an undergraduate student, the obtained data showed that approximately 75% of the European Northern human population demonstrate the expression of a phenotype directly associated with the homozygous dominant genotype, while 25% display the mutant phenotype despite their genotypes being homozygous dominant. Using your knowledge propose two hypotheses for this observation.arrow_forwardThe use of nucleotide sequence data to measure genetic variability is complicated by the fact that the genes of higher eukaryotes are complex in organization and contain 5′ and 3′ flanking regions as well as introns. Researchers have compared the nucleotide sequence of two cloned alleles of the g-globin gene from a single individual and found a variation of 1 percent. Those differences include 13 substitutions of one nucleotide for another and 3 short DNA segments that have been inserted in one allele or deleted in the other. None of the changes takes place in the gene’s exons (coding regions). Why do you think this is so, and should it change our concept of genetic variation?arrow_forward(1B) Think of and identify a modern-day problem that can be solved by Genetic Engineering. If you were a scientist, what unique characteristics (at least 3) will be exhibited by the GMO that will solve the problem? Briefly describe eacharrow_forward
- Suppose a genome-wide association study(GWAS) investigation found a particularsingle nucleotide polymorphism (SNP) in acertain gene to be associated withhypertension. How could you identify thecausal link of the specific SNP tohypertension?arrow_forwardPropose a hypotheses for this observation: In a study conducted by an undergraduate student, he obtained data showing that approximately 75% of the European Northern human population demonstrate the expression of a phenotype directly associated with the homozygous dominant genotype, while 25% display the mutant phenotype despite their genotypes being homozygous dominant.arrow_forwardFor the expression of traits gene provide only the potentialily and the environment provides the opportunity.comment on the statement?arrow_forward
- Name the common and rare alleles found in the human population of the TAS2R38 gene.arrow_forwardYou found a strain of mutant fruit flies (Drosophila) living on the rotten bananas in your dorm room. You notice that many of the larvae have abnormal abdominal segments. You want to know if the “abdomenless” mutation is a maternal effect gene. Describe an experiment you would do to determine this, and the results that would support and contradict the notion that the abdomenless gene encodes a maternal determinant.arrow_forwardAre the following examples a description of genetics at the molecular, cellular, organismal, or populational level? A. People with cystic fibrosis have lung problems due to a buildup of mucus in their lungs B. The mutant CF gene encodes a chloride transporter that doesn't transport chloride ions very well. C. A defect in the chloride transporter causes a salt imbalance in lung cells.arrow_forward
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