Genetics: From Genes to Genomes
Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 22, Problem 12P

Two alleles at one locus produce three distinct phenotypes. Two alleles of two genes lead to five distinct phenotypes. Two alleles of six genes lead to 13 distinct phenotypes. (These statements assume that the alleles at any one locus are codominant or incompletely dominant and that each gene makes an equal contribution to the phenotype.)

a. Derive a formula to express this relationship. (Let n equal the number of genes.)
b. Each of the most extreme phenotypes for a trait determined by two alleles at one locus are found in a proportion of 1/4 in the F2 generation. If two alleles of two genes determine the trait, each extreme phenotype will be present in the F2 as 1/16 of the population.
In common wheat (Triticum aestivum), kernel color varies from red to white and the genes controlling the color act additively, that is, alleles for each gene are incompletely dominant and each gene contributes equally to the color. A true-breeding red variety is crossed to a true-breeding white variety, and 1/256 of the F2 have red kernels and 1/256 have white kernels. How many genes control kernel color in this cross?
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In humans, the genetic disease cystic fibrosis is caused by a recessive allele (a). The normal (healthy) allele is dominant (A). What is the genotype of someone who has cystic fibrosis?   What are the two different genotypes that a healthy person could have?   If two people were both heterozygous for the cystic fibrosis gene, what fraction of their children would be likely to have this disease? Hint: Draw a Punnett square to figure it out.
Assume that plant weight is determined by a pair of alleles at each of two independently assorting loci (A and a, B and b) that are additive in their effects. Further assume that each allele represented by an uppercase letter contributes 4 g to weight and that each allele represented by a lowercase letter contributes 1 g to weight. a. If a plant with genotype AA BB is crossed with a plant with genotype aa bb, what weights are expected in the F1 progeny? b. What is the distribution of weight expected in the F2 progeny?
The father of two children is type O+, and the mother is type A+. The children are O- and A+. Given this information, what are the genotypes of the father vs. the mother at both the “I” and “Rh” alleles? Explain your rationale.

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Genetics: From Genes to Genomes

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