Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 22, Problem 28P
In domesticated dogs, size has a high heritability, and the trait is determined by only a small number of genes. In contrast,
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In domesticated dogs, size has a high heritability, andthe trait is determined by only a small number ofgenes. In contrast, genetic variation at more than180 QTLs explains only a very small proportion ofthe high heritability for height in humans. What couldexplain the missing heritability in humans, and howcould you test your hypothesized explanations?
In a horse population, three different traits showing continuous distribution were measured,and their variances are shown in the table below:(see image)
1. Calculate the broad sense and narrow sense heritabilities for each trait.2. In the population of animals studied, which trait would respond best to selection for breeding purposes? Explain your answer.
We have learned that the response to selection is equal to the selection differential times the narrow-sense heritability, and that the narrowsense heritability includes only the additive genetic variance. Why aren’t the dominance genetic variance and the gene interaction variance included? Why don’t they contribute to the genetic variation that is acted on by selection?
Chapter 22 Solutions
Genetics: From Genes to Genomes
Ch. 22 - Choose the best matching phrase in the right...Ch. 22 - Suppose you grew genetically identical dandelion...Ch. 22 - How can each of the following be used in...Ch. 22 - Two different groups of scientists studying a rare...Ch. 22 - Which of the following statements would be true of...Ch. 22 - Studies have indicated that for pairs of twins...Ch. 22 - Prob. 7PCh. 22 - Prob. 8PCh. 22 - Table 22.2 lists concordance values for MZ and DZ...Ch. 22 - Prob. 10P
Ch. 22 - Prob. 11PCh. 22 - Two alleles at one locus produce three distinct...Ch. 22 - In a certain plant, leaf size is determined by...Ch. 22 - Compare and contrast the use of SNP genotyping: i...Ch. 22 - Explain the similarities and differences between...Ch. 22 - In Fig. 22.14c, the fw2.2 causal gene was...Ch. 22 - Among the most prevalent pathologies that afflict...Ch. 22 - Human geneticists have found the Finnish...Ch. 22 - Canavan disease, caused by homozygosity for a...Ch. 22 - In GWAS analysis, because of the existence of LD...Ch. 22 - In Fig. 22.15: a. Why do some chromosomes in the...Ch. 22 - Consider the triangle diagram shown in Fig. 22.17....Ch. 22 - Prob. 23PCh. 22 - You conduct a Case/Control study comparing the...Ch. 22 - Prob. 25PCh. 22 - ALS amyotrophic lateral sclerosis is a rare, fatal...Ch. 22 - Through GWAS explorations, scientists have...Ch. 22 - In domesticated dogs, size has a high...Ch. 22 - Suppose a GWAS investigation found a particular LD...Ch. 22 - In 2008, Time magazine named as its invention of...
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- . In pea plants, height is controlled by a Dominant Allele (T) for Tall Height and by a Recessive Allele (t) for Short Height. If 96% of a population of pea plants have the tall phenotype, calculate the frequencies of dominant allele (T) & recessive (t) alleles. Out of the 96%, what is the estimation of how many are homozygous dominant vs. heterozygous? What is the frequency of the recessive phenotype?arrow_forwardHow can we explain the striking contrast in the number of major genes underlying quantitative traits between domesticated animals (where only a few QTLs are typically involved) and humans (where the QTLs for manytraits number in the hundreds)?arrow_forwardIf a trait determined by autosomal recessive allele occurs at a frequency of 0.25 in a population, what are the allelic frequencies? Assume Hardy-Weinberg equilibrium and use A and a to symbolize the dominant and recessive alleles, respectively. Show calculation.arrow_forward
- If there is no genetic variation within a population for a given trait, what is the heritability for the trait in the population?arrow_forwardYou are a rabbit breeder, and you decide that you want rabbits with long fur. Thephenotypic variance of fur length is 4 cm2. The covariance of fur length between betweenfull sibs is 1 cm2. The mean fur length in the initial population is 3 cm. You choose to breedthe top 1/3 of the population with the longest fur, and their mean fur length is 5 cm. Assumethat the covariance between sibs is due to only additive genetic variance.a) What is the narrow sense heritability (h^2 ) of fur length?b) What do you expect the mean fur length to be in the progeny of rabbits you breed?c) How many generations of this selection regime will it take for the mean fur length of thepopulation to be 10 cm? (Assume heritability and additive genetic variance remainunchanged throughout this process.)arrow_forwardThe Allen's and Bergmann's rule can help to explain variation between regional populations for which of the following phenotypes? Group of answer choices Nose form Stature (height) Milk sugar digestion Skin, hair and eye color Intelligencearrow_forward
- Pigs have been domesticated from wild boars. Would you expect to find higher heritability for weight among domesticated pigs or wild boars? Explain your answerarrow_forwardA genetics researcher determines that the broad-sense heritability of height among Southwestern University undergraduate students is 0.90. Which of the following conclusions would be reasonable? Explain your answer. a. Sally is a Southwestern University undergraduate student, so 10% of her height is determined by nongenetic factors. b. Ninety percent of variation in height among all undergraduate students in the United States is due to genetic differences. c. Ninety percent of the height of Southwestern University undergraduate students is determined by genes. d. Ten percent of the variation in height among Southwestern University undergraduate students is determined by variation in nongenetic factors. e. Because the heritability of height among Southwestern University students is so high, any change in the students’ environment will have minimal effect on their height.arrow_forwardIn a large herd of 5468 sheep, 76 animals have yellow fat, and the rest of the members of the herd have white fat. Yellow fat is inherited as a recessive trait. This herd is assumed to be in Hardy-Weinberg equilibrium. A. What are the frequencies of the white and yellow fat alleles in this population? B. Approximately how many sheep with white fat are heterozygous carriers of the yellow allele?arrow_forward
- Suppose that in a population of Peacocks the phenotypic variance for tail length is 2.5 and the heritability for this trait is 0.4. From a long-term captive population you also have data from a line of completely inbred individuals. In this line the phenotypic variance among individuals is 0.50. Assume that there is no epistatic variance (VI) for this trait. Calculate the following: What is the total genetic variance for tail length? What is the additive genetic variance? What is the dominance genetic variance? What is the environmental variance? What is the broad-sense heritability (H2)?arrow_forwardThe ability to taste the compound PTC is controlled by a dominant allele T, while individuals homozygous for the recessive allele (t) cannot taste PTC. In a population consisting of 500 individuals, 347 are tasters and 153 are non-PTC tasters. Calculate the frequency of the T and t alleles in this population, and frequency of the genotypes. (Please train yourself to use the Hardy-Weinberg equation.)arrow_forwardSuppose that in a population of Peacocks the phenotypic variance for tail length is 2.5 and the heritability for this trait is 0.4. From a long-term captive population you also have data from a line of completely inbred individuals. In this line the phenotypic variance among individuals is 0.50. Assume that there is no epistatic variance (VI) for this trait. Calculate the following: What is the additive genetic variance? What is the dominance genetic variance? What is the environmental variance? What is the broad-sense heritability (H2)?arrow_forward
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