Genetics: From Genes to Genomes
Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 22, Problem 28P

In domesticated dogs, size has a high heritability, and the trait is determined by only a small number of genes. In contrast, genetic variation at more than 180 QTLs explains only a very small proportion of the high heritability for height in humans. What could explain the missing heritability in humans, and how could you test your hypothesized explanations?

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In domesticated dogs, size has a high heritability, andthe trait is determined by only a small number ofgenes. In contrast, genetic variation at more than180 QTLs explains only a very small proportion ofthe high heritability for height in humans. What couldexplain the missing heritability in humans, and howcould you test your hypothesized explanations?
In a horse population, three different traits showing continuous distribution were measured,and their variances are shown in the table below:(see image) 1. Calculate the broad sense and narrow sense heritabilities for each trait.2. In the population of animals studied, which trait would respond best to selection for breeding purposes? Explain your answer.
We have learned that the response to selection is equal to the selection differential times the narrow-sense heritability, and that the narrowsense heritability includes only the additive genetic variance. Why aren’t the dominance genetic variance and the gene interaction variance included? Why don’t they contribute to the genetic variation that is acted on by selection?

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Genetics: From Genes to Genomes

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