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Chemistry

9th Edition
Steven S. Zumdahl
ISBN: 9781133611097

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BuyFindarrow_forward

Chemistry

9th Edition
Steven S. Zumdahl
ISBN: 9781133611097
Textbook Problem

Over 100 different kinds of mutant hemoglobin molecules have been detected in humans. Unlike sickle cell anemia (see Exercise 93), not all of these mutations are as serious. In one nonlethal mutation, glutamine substitutes for a single glutamic acid in normal hemoglobin. Rationalize why this substitution is nonlethal.

Interpretation Introduction

Interpretation: The nonlethal substitution for single glutamic acid in normal hemoglobin by glutamine is to be explained.

Concept introduction: Amino acids are defined as organic compounds which contain amine (NH2) and carboxyl (COOH) functional groups, along with a side chain (R group) attached to each amino acid. Hemoglobin is an oxygen transport metalloprotein, containing iron as a central metal atom. Glutamic acid and glutamine are amino acids produced in the muscles and are used in the biosynthesis of proteins.

To determine: The explanation for a nonlethal substitution of glutamic acid by glutamine in hemoglobin.

Explanation

Explanation

The structures of glutamic acid and glutamine are,

Figure 1

Glutamic acid is an α -amino acid having a molecular formula of C5H9O4N and the molecular formula of Glutamine is

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Chapter 22 Solutions

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Ch-22 P-11RQCh-22 P-12RQCh-22 P-1QCh-22 P-2QCh-22 P-3QCh-22 P-4QCh-22 P-5QCh-22 P-6QCh-22 P-7QCh-22 P-8QCh-22 P-9QCh-22 P-10QCh-22 P-11QCh-22 P-12QCh-22 P-13ECh-22 P-14ECh-22 P-15ECh-22 P-16ECh-22 P-17ECh-22 P-18ECh-22 P-19ECh-22 P-20ECh-22 P-21ECh-22 P-22ECh-22 P-23ECh-22 P-24ECh-22 P-25ECh-22 P-26ECh-22 P-27ECh-22 P-28ECh-22 P-29ECh-22 P-30ECh-22 P-31ECh-22 P-32ECh-22 P-33ECh-22 P-34ECh-22 P-35ECh-22 P-36ECh-22 P-37ECh-22 P-38ECh-22 P-39ECh-22 P-40ECh-22 P-41ECh-22 P-42ECh-22 P-43ECh-22 P-44ECh-22 P-45ECh-22 P-46ECh-22 P-47ECh-22 P-48ECh-22 P-49ECh-22 P-50ECh-22 P-51ECh-22 P-52ECh-22 P-53ECh-22 P-54ECh-22 P-55ECh-22 P-56ECh-22 P-57ECh-22 P-58ECh-22 P-59ECh-22 P-60ECh-22 P-61ECh-22 P-62ECh-22 P-63ECh-22 P-64ECh-22 P-65ECh-22 P-66ECh-22 P-67ECh-22 P-68ECh-22 P-69ECh-22 P-70ECh-22 P-71ECh-22 P-72ECh-22 P-73ECh-22 P-74ECh-22 P-75ECh-22 P-76ECh-22 P-77ECh-22 P-78ECh-22 P-79ECh-22 P-80ECh-22 P-81ECh-22 P-82ECh-22 P-83ECh-22 P-84ECh-22 P-85ECh-22 P-86ECh-22 P-87ECh-22 P-88ECh-22 P-89ECh-22 P-90ECh-22 P-91ECh-22 P-92ECh-22 P-93ECh-22 P-94ECh-22 P-95ECh-22 P-96ECh-22 P-97ECh-22 P-98ECh-22 P-99ECh-22 P-100ECh-22 P-101ECh-22 P-102ECh-22 P-103ECh-22 P-104ECh-22 P-105ECh-22 P-106ECh-22 P-107ECh-22 P-108ECh-22 P-109ECh-22 P-110ECh-22 P-111AECh-22 P-112AECh-22 P-113AECh-22 P-114AECh-22 P-115AECh-22 P-116AECh-22 P-117AECh-22 P-118AECh-22 P-119AECh-22 P-120AECh-22 P-121AECh-22 P-122AECh-22 P-123AECh-22 P-124AECh-22 P-125AECh-22 P-126AECh-22 P-127AECh-22 P-128AECh-22 P-129AECh-22 P-130AECh-22 P-131AECh-22 P-132AECh-22 P-133AECh-22 P-134AECh-22 P-135AECh-22 P-136AECh-22 P-137CWPCh-22 P-138CWPCh-22 P-139CWPCh-22 P-140CWPCh-22 P-141CWPCh-22 P-142CWPCh-22 P-143CWPCh-22 P-144CWPCh-22 P-145CPCh-22 P-146CPCh-22 P-147CPCh-22 P-148CPCh-22 P-149CPCh-22 P-150CPCh-22 P-151CPCh-22 P-152CPCh-22 P-153CPCh-22 P-154CPCh-22 P-155CPCh-22 P-156CPCh-22 P-157CPCh-22 P-158CPCh-22 P-159IPCh-22 P-160IPCh-22 P-161MPCh-22 P-162MP

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