(a) Interpretation: The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly − Lys − Ala using the solid-phase method is to be stated. Concept introduction: Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 1

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Treatment of a new protein with dansyl chloride reveals two (2) dansyl-labelled derivatives of amino acids, alanine and methionine. What can you deduce about the structure of the proteinfrom these results?

Determine the amino acid sequence of a polypeptide from the following data:Acid-catalyzed hydrolysis gives Ala, Arg, His, 2 Lys, Leu, 2 Met, Pro, 2 Ser, Thr, and Val.Carboxypeptidase A releases Val.Edman’s reagent releases PTH-Leu.Treatment with cyanogen bromide gives three peptides with the following amino acid compositions:1. His, Lys, Met, Pro, Ser 2. Thr, Val 3. Ala, Arg, Leu, Lys, Met, Ser

An amino acid mixture of phenylalanine, glycine and glutamic acid is to be separated bypaper chromatography. The solvent is less polar than water. Which of these amino acids will have the highest Rf value and which the lowest? Explain. Treatment of a new protein with dansyl chloride reveals two (2) dansyl-labelled derivatives of amino acids, alanine and methionine. What can you deduce about the structure of the protein from these results? Name the amino acids that contribute atoms to both purine and pyrimidine rings.

Answer 2

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 3

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 4

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 5

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 6

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 7

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 27 - Prob. 27.1P Ch. 27 - Prob. 27.2P Ch. 27 - Prob. 27.3P Ch. 27 - Prob. 27.4P Ch. 27 - Prob. 27.5P Ch. 27 - Prob. 27.6P Ch. 27 - Prob. 27.8P Ch. 27 - Prob. 27.9P Ch. 27 - Prob. 27.10P Ch. 27 - Prob. 27.11P

Solution Summary: The author explains solid-phase peptide synthesis, wherein lysine is protected from both the amine and carboxyl groups.

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Chapter 27 Solutions