EBK ORGANIC CHEMISTRY
6th Edition
ISBN: 8220103151757
Author: LOUDON
Publisher: MAC HIGHER
expand_more
expand_more
format_list_bulleted
Question
Chapter 27, Problem 27.65AP
Interpretation Introduction
Interpretation:
The reason as to why the peptide is removed from more sensitive linker with much more dilute acid than required for the given linker is to be stated.
Concept introduction:
Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Thoroughly explain why (a)malthose is a reducing sugar while trehalose is not based on their structures. (b)Why is trehalose very resistant to acid hydrolysis while maltose can be acid-hydrolyzed with ease. Give clear explanations.
The activity of sulphonamides is decreased if they are taken at the same time as procaine. Suggest why this might be the case.
Explain, please.
Enalapril is an anti-hypertension "prodrug" (i.e, a drug precursor) that is inactive until the ethyl ester (arrow in figure) is hydrolyzed by esterases present in blood plasma. The active drug is the dicarboxylic acid ("enalaprilat") that results from this hydrolysis reaction. (a) Enalapril is administered in pill form, but enalaprilat must be akdministered intravenously. Why do you suppose enalapril works as a pill, but enalaprilat does not? EtOoC -NH CH3 HOOC Enalapril (b) Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACE), which cleaves the blood-pressure regulating peptide angiotensin. ACE has a KM = 12 µM for angiotensin, which is present in plasma at a concentration of 75 µM. When enalaprilat is present at 2.4 nM, the activity of ACE in plasma is 10% of its uninhib- ited activity. What is the value of K; for enalaprilat?
Chapter 27 Solutions
EBK ORGANIC CHEMISTRY
Ch. 27 - Prob. 27.1PCh. 27 - Prob. 27.2PCh. 27 - Prob. 27.3PCh. 27 - Prob. 27.4PCh. 27 - Prob. 27.5PCh. 27 - Prob. 27.6PCh. 27 - Prob. 27.8PCh. 27 - Prob. 27.9PCh. 27 - Prob. 27.10PCh. 27 - Prob. 27.11P
Ch. 27 - Prob. 27.12PCh. 27 - Prob. 27.13PCh. 27 - Prob. 27.14PCh. 27 - Prob. 27.15PCh. 27 - Prob. 27.16PCh. 27 - Prob. 27.17PCh. 27 - Prob. 27.18PCh. 27 - Prob. 27.19PCh. 27 - Prob. 27.20PCh. 27 - Prob. 27.21PCh. 27 - Prob. 27.22PCh. 27 - Prob. 27.23PCh. 27 - Prob. 27.24PCh. 27 - Prob. 27.25PCh. 27 - Prob. 27.26PCh. 27 - Prob. 27.27PCh. 27 - Prob. 27.28PCh. 27 - Prob. 27.29PCh. 27 - Prob. 27.30PCh. 27 - Prob. 27.31PCh. 27 - Prob. 27.32PCh. 27 - Prob. 27.33PCh. 27 - Prob. 27.34PCh. 27 - Prob. 27.35PCh. 27 - Prob. 27.36PCh. 27 - Prob. 27.37PCh. 27 - Prob. 27.38PCh. 27 - Prob. 27.39PCh. 27 - Prob. 27.40PCh. 27 - Prob. 27.41PCh. 27 - Prob. 27.42PCh. 27 - Prob. 27.43APCh. 27 - Prob. 27.44APCh. 27 - Prob. 27.45APCh. 27 - Prob. 27.46APCh. 27 - Prob. 27.47APCh. 27 - Prob. 27.48APCh. 27 - Prob. 27.49APCh. 27 - Prob. 27.50APCh. 27 - Prob. 27.51APCh. 27 - Prob. 27.52APCh. 27 - Prob. 27.53APCh. 27 - Prob. 27.54APCh. 27 - Prob. 27.55APCh. 27 - Prob. 27.56APCh. 27 - Prob. 27.57APCh. 27 - Prob. 27.58APCh. 27 - Prob. 27.59APCh. 27 - Prob. 27.60APCh. 27 - Prob. 27.61APCh. 27 - Prob. 27.62APCh. 27 - Prob. 27.63APCh. 27 - Prob. 27.64APCh. 27 - Prob. 27.65APCh. 27 - Prob. 27.66APCh. 27 - Prob. 27.67APCh. 27 - Prob. 27.68APCh. 27 - Prob. 27.69APCh. 27 - Prob. 27.70APCh. 27 - Prob. 27.71APCh. 27 - Prob. 27.72APCh. 27 - Prob. 27.73APCh. 27 - Prob. 27.74APCh. 27 - Prob. 27.75APCh. 27 - Prob. 27.76APCh. 27 - Prob. 27.77APCh. 27 - Prob. 27.78APCh. 27 - Prob. 27.79APCh. 27 - Prob. 27.80APCh. 27 - Prob. 27.81APCh. 27 - Prob. 27.82APCh. 27 - Prob. 27.83AP
Knowledge Booster
Similar questions
- (d) Would the polymer C be expected to undergo a non-chain scission degradation reaction or a photooxidative degradative process? Explain your answer fully.arrow_forwardAMINO ACIDS AND PEPTIDES 1. Answer ALL parts. a) Detail how you would use the amidomalonate synthesis to prepare a racemic mixture of leucine. Include in your answer a mechanism for the reaction.arrow_forwardA student was attempting to prepare chiral amine with the structure shown below. After numerous attempts, each sample turned out to be optically inactive. Briefly explain why the synthesis was unsuccessful. N..arrow_forward
- According to the paper, F486 is a phenylalanine residue (i.e., an amino acid that is part of a chain that forms a protein) on SARS-CoV-2. It has an important interaction with ACE2 (best seen in Fig. 1(C) and Fig. 2(A)). Looking at this phenylalanine and the green residues surrounding it, which statement best describes the interaction that could be occurring? a) It forms a hydrogen bond with Y83. b) It forms a dipole-dipole interaction with M82. c) It forms London dispersion forces with surrounding residues. d) It encounters repulsions from surrounding residues.arrow_forwardGive the amine and coupling component of the given compound.arrow_forward(b) Explain why`the 'H-NMR of primary amides experience observable broadening of. –NH protons.arrow_forward
- How would you account for the following :(a) Electrophilic susbstitution in case of aromatic amines takes place more readily than benzene.(b) Ethanamide is a weaker base than ethanamine.arrow_forwardThe stability of our genetic code depends on the stability of DNA. We are fortunate that the aminoacetal linkages ofDNA are not easily cleaved. Show why your mechanism for part (a) does not work so well with deoxycytidine anddeoxyadenosine.arrow_forward(Part 1) Using chem draw or any chemical drawing program, show the reactants and products of the following polymer reactions. You may use n to represent the number of units. Your figures should be in line angle. (Part 2) Draw the mechanism for at least one of the polyacrylamide and one of the sodium polyacrylamide reactions, being consistent in which counter reactant you use. (a) polyacrylamide and water (b) polyacrylamide and isopropyl alcohol (c) polyacrylamide and saturated sodium chloride (d) sodium polyacrylamide and water (e) sodium polyacrylamide and isopropyl alcohol (f) sodium polyacrylamide and saturated sodium chloridearrow_forward
- ers and additional paper if necessary.) 3. Vasopressin, a substance produced by the human body that regulates blood volume and pressure, is a nonapeptide with the following amino acid sequence. Describe the results you would expect when vaso- pressin is tested with the following reagents. Note: The amino acid asparagine, ASN, is struc- turally similar to glutamine. The only difference is that asparagine has one fewer CH, group in its side chain than glutamine. GLY-ARG-PRO-CYS-ASN-GLN-PHE-TYR-CYS human vasopressin test observation done (1) xanthoproteic (2) Millon's (3) Hopkins-Cole (4) nitroprusside groiliod nice philiod br feel drl noM prinsmoo enoituloa taet erit bisoela er sladet bns oounle w padui dasl eiieeW pesinoleb 1o boll sldleenoo cw rloum ee ovometarrow_forward(a) Which is more reactive towards Electrophilic aromatic substitution (EAS)? (b) Which of the following is a a meta-substituted compound? (c) Which is the least reactive towards Electrophilic aromatic substitution (EAS)? (d) Which is an ortho-substituted compound?arrow_forwardExperimental control is most clearly facilitated by means of…arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning
Organic Chemistry
Chemistry
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:Cengage Learning