Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 3, Problem 26P
In humans, SRY is located near a pseudoautosomal region (PAR) of the Y chromosome, a region of homology between the X and Y chromosomes that allows them to synapse during meiosis in males and is a region of crossover between the chromosomes. The diagram below shows SRY in relation to the pseudoautosomal region.
About 1 in every 25,000 newborn infants is born with sex reversal; the infant is either an apparent male, but with two X chromosomes, or an apparent female, but with an X and a Y chromosome. Explain the origin of sex reversalin human males and females involving the SRY gene. (Hint: See Experimental Insight 3.1 for a clue about the mutational mechanism.)
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Butterflies have an X-Y sex-determination system that is different from that of flies or humans. Female butterflies may be either XY or X0, while butterflies with two or more X chromosomes are males. This photograph shows a tiger swallowtail gynandromorph, which is half male (left side) and half female (right side). Given that the first division of the zygote divides the embryo into the future right and left halves of the butterfly, propose a hypothesis that explains how nondisjunction during the first mitosis might have produced this unusual-looking butterfly.
Question is also in the picture.
Chromosomal nondisjunction of the X chromosome in female gametes of humans means that live offspring can include ________.
A) females with XX or XXX, and males with XY or XXY
B) females with XX, and males with XY
C) females with XX, and males with XY or XO
D) females with XX or XXX, and males with XY or XO
E) females with XX or XO, and males with XY or OY
crossing over within a pericentric inversion produces chromosomes that have extra copies of some genes and no copies of other genes. The fertilization of gametes containing chromosomes with duplications or deletions often result in children with syndromes characterized by developmental delay, intellectual disability, abnormal development of organ systems, and early death. Maarit Jaarola and colleagues examined individual sperm cells of a male who was heterozygous for a pericentric inversion on chromosome 8 and determined that crossing over took place within the pericentric inversion in 26% of the meiotic divisions (M. Jaarola, R. H. Martin, and T. Ashley. 1998. American Journal of Human Genetics 63:218–224). Assume that you are a genetic counselor and that a couple seeks counseling from you. Both the man and the woman are phenotypically normal, but the woman is heterozygous for a pericentric inversion on chromosome 8. The man is karyotypically normal. What is the probability that this…
Chapter 3 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 3 - Examine the following diagrams of cells from an...Ch. 3 - Our closest primate relative, the chimpanzee, has...Ch. 3 -
3. In a test of his chromosome theory of...Ch. 3 - Cohesion between sister chromatids, as well as...Ch. 3 - 5. The diploid number of the hypothetical animal...Ch. 3 - 6. An organism has alleles R1 and R2 on one pair...Ch. 3 - Explain how the behavior of homologous chromosomes...Ch. 3 - 8. Suppose crossover occurs between the homologous...Ch. 3 -
9. Alleles A and a are on one pair of autosomes,...Ch. 3 - Prob. 10P
Ch. 3 - Describe the role of the following structures or...Ch. 3 - A womans father has ornithine transcarbamylase...Ch. 3 - In humans, hemophilia A (OMIM 306700) is an...Ch. 3 -
14. A wild-type male and a wild-type female...Ch. 3 - 15. A woman with severe discoloration of her tooth...Ch. 3 - 16. In a large metropolitan hospital, cells from...Ch. 3 - In cats, tortoiseshell coat color appears in...Ch. 3 - 18. The gene causing Coffin–Lowry syndrome (OMIM...Ch. 3 - 19. Four eye-color mutants in Drosophila—apricot,...Ch. 3 - 20. For each pedigree shown,
a. Identify which...Ch. 3 - 21. Use the blank pedigrees provided to depict...Ch. 3 - 22. Figure 3.22 (page 89) illustrates reciprocal...Ch. 3 - 23. In fruit flies, yellow body (y) is recessive...Ch. 3 - 24. In a species of fish, a black spot on the...Ch. 3 - LeschNyhan syndrome (OMIM 300322) is a rare...Ch. 3 - 26. In humans, SRY is located near a...Ch. 3 - 27. In an 1889 book titled Natural Inheritance...Ch. 3 - 30. Drosophila has a diploid chromosome number of...Ch. 3 - 29. A wild-type Drosophila male and female are...Ch. 3 - 28. In Drosophila, the X-linked echinus eye...Ch. 3 - 31. While examining a young tortoiseshell cat, you...Ch. 3 - 32. Redgreen color blindness in humans is...
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- Assume that a meiotic-nondisjunction event causes trisomy 8 in a newborn. If two of the three copies of chromosome 8 are absolutely identical, at what point during meiosis did the nondisjunction event take place?arrow_forwardHuman females have two X chromosomes XX; males have one X and one Y chromosome XY. a. With respect to X-linked alleles, how many different types of gametes can a male produce? b. A female homozygous for an X-linked allele can produce how many types of gametes with respect to that allele? c. A female heterozygous for an X-linked allele can produce how many types of gametes with respect to that allele?arrow_forward. With regards to the grasshopper testes experiment, diakinesis is an ideal stage to determine chromosome number due to the degree of condensation of the chromosomes? Count the chromosomes at this stage. Does it represent a diploid or a haploid number?arrow_forward
- In a diploid organism, two homologous chromosomes synapse at prophase 1 of meiosis. One of the homologous chromosomes carries a sequence of four genes named A, B, C, and D. They get capital letters because each gene is dominant. On the two chromatids of the homologous chromosome, the same sequence of genes are all recessive. They are denoted a, b, c, and d. During prophase I of meiosis, when the homologous chromosomes synapse with one another, there is a crossover between two of the non-sister chromatid. These two chromatids break between genes B and C, as shown in the diagram below. They then reattach to the non-sister chromatid. What will each of these 2 chromatids carry after they separate from their sister chromatid in meiosis 2?arrow_forwardConsider a cell with 2 pairs of homologous chromosomes where Chromosome 1 with genes VWXYZ is the homolog of Chromosome 2 with genes vwxyz while Chromosome 3 with genes PQRST is the homolog of Chromosome 4 with genes parst. If a reciprocal translocation occurred between Chromosome 1 YZ genes and Chromosome 3 ST genes, give the following gamete types produced after meiosis: (Answer in Arabic numbers only) 1. Gamete/s with non-recombinant chromosomes 2. Gamete/s with 1 recombinant chromosome 3. Gamete/s with 2 recombinant chromosomes 4. Gamete/s with gene duplications 5. Gamete/s with gene deletions 6. Gamete/s with 2 normal chromosome sequences 7. Gamete/s with 1 normal chromosome sequence 8. Gamete/s with balanced translocation 9. Gametes/ with all dominant genes 10. Gamete/s with all recessive genes 11. Gamete/s with 10 different genes 12. Gamete/s with TSXWV genes 13. Gamete/s with vwxyz genes 14. Gamete/s with pqrst genes 15.Gamete/s with PORYZarrow_forwardIn elegans, lon-2 and unc-2 are recessive mutations that are 8 map units apart on the X chromosome. An hermaphrodite who is Lon and Unc is mated to a wild-type male. An F1 hermaphrodite is mated to a wild-type male. What are the expected percentages of the different recombinant phenotypes among the male progeny?arrow_forward
- A cell has four pairs of chromosomes. Assuming that crossing over does not occur, what is the probability that a gamete will contain all of the paternal chromosomes? If n equals the number of chromosomes in a set, which of the following expressions can be used to calculate the probability that a gamete will receive all of the paternal chromosomes: (1/2)n, (1/2)n–1, or n1/2?arrow_forwardIn C. elegans, lon-2 and unc-2 are recessive mutations that are 8 map units apart on the X chromosome. An hermaphrodite who is Lon and Unc is mated to a wild-type male. An F1 hermaphrodite is mated to a wild-type male. What are the expected percentages of the different phenotypes among the male progeny?arrow_forward. A mature female wolf, with 78 diploid chromosomes in each somatic cell, produces haploid oocytes (egg cells) containing how many chromosomes per cell? 1 sex-determining chromosome (Y) and 38 autosomes 2 sex-determining chromosomes (XX) and 76 autosomes 1 sex-determining chromosome (X) and 39 autosomes 2 sex-determining chromosomes (XY) and 76 autosomes 1 sex-determining chromosome (X) and 38 autosomesarrow_forward
- In Drosophila, the X chromosomes may become attached to one another (XXn ) such that they always segregate together. Some flies thus contain a set of attached X chromosomes plus a Y chromosome. (a) What sex would such a fly be? Explain why this is so. (b) Given the answer to part (a), predict the sex of the off-spring that would occur in a cross between this fly and a normal one of the opposite sex. (c) If the offspring described in part (b) are allowed to interbreed, what will be the outcome?arrow_forwardIn mice, the Sry gene is located on the Y chromosome very close to one of the pseudoautosomal regions that pairs with the X chromosome during male meiosis. Given this information, propose a model to explain the generation of unusual males who have two X chromosomes (with an Sry-containing piece of the Y chromosome attached to one X chromosome).arrow_forwardIn certain salamanders, the sex of a genetic female can be altered, changing her into a functional male; these salamanders are called sex reversed males. When a sex-reversed male is mated with a normal female, approximately 23 of the offspring are female and 13 are male. How is sex determined in these salamanders? Explain the results of this crossarrow_forward
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