Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 3, Problem 42P
Familial hypercholesterolemia (FH) is an inherited trait in humans that results in higher than normal serum cholesterol levels (measured in milligrams of cholesterol per deciliter of blood [mg/dl]). People with serum cholesterol levels that are roughly twice normal have a 25 times higher frequency of heart attacks than unaffected individuals. People with serum cholesterol levels three or more times higher than normal have severely blocked arteries and almost always die before they reach the age of 20. The following pedigrees show the occurrence of FH in four Japanese families:
| a. | What is the most likely mode of inheritance of FH based on these data? Are there any individuals in any of these pedigrees who do not fit your hypothesis? What special conditions might account for such individuals? |
| b. | Why do individuals in the same |
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Chapter 3 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 3 - For each of the terms in the left column, choose...Ch. 3 - In four-oclocks, the allele for red flowers is...Ch. 3 - The Aa heterozygous snapdragons in Fig. 3.3 are...Ch. 3 - In the fruit fly Drosophila melanogaster, very...Ch. 3 - A cross between two plants that both have yellow...Ch. 3 - In radishes, color and shape are each controlled...Ch. 3 - A wild legume with white flowers and long pods is...Ch. 3 - Prob. 8PCh. 3 - Assuming no involvement of the Bombay phenotype:...Ch. 3 - Several genes in humans in addition to the ABO...
Ch. 3 - Alleles of the gene that determines seed coat...Ch. 3 - Prob. 12PCh. 3 - In a population of rabbits, you find three...Ch. 3 - In clover plants, the pattern on the leaves is...Ch. 3 - Fruit flies with one allele for curly wings Cy and...Ch. 3 - Prob. 16PCh. 3 - In a species of tropical fish, a colorful orange...Ch. 3 - A rooster with a particular comb morphology called...Ch. 3 - A black mare was crossed to a chestnut stallion...Ch. 3 - Prob. 20PCh. 3 - Prob. 21PCh. 3 - a. How could you describe inheritance of flower...Ch. 3 - Explain the difference between epistasis and...Ch. 3 - The dominant allele H reduces the number of body...Ch. 3 - Secretors genotypes SS and Ss secrete their A and...Ch. 3 - Normally, wild violets have yellow petals with...Ch. 3 - Prob. 27PCh. 3 - Three different pure-breeding strains of corn that...Ch. 3 - In mice, the AY allele of the agouti gene is a...Ch. 3 - A student whose hobby was fishing pulled a very...Ch. 3 - Prob. 31PCh. 3 - Prob. 32PCh. 3 - Three genes in fruit flies affect a particular...Ch. 3 - The garden flower Salpiglossis sinuata painted...Ch. 3 - In foxgloves, there are three different petal...Ch. 3 - In a culture of fruit flies, matings between any...Ch. 3 - Suppose that blue flower color in a plant species...Ch. 3 - Prob. 38PCh. 3 - Considering your answers to Problem 38, does the...Ch. 3 - Prob. 40PCh. 3 - Prob. 41PCh. 3 - Familial hypercholesterolemia FH is an inherited...Ch. 3 - You have come into contact with two unrelated...Ch. 3 - Polycystic kidney disease is a dominant trait that...Ch. 3 - Using each of the seven coat color genes discussed...
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