Concept explainers
a.
To determine:
The genotype of a person that has sickle-cell anemia.
Introduction:
The genes are the basic unit of inheritance. The different characteristics of an individual are provided by the genes obtained from both the parents. Each parent provides a haploid set of genes.
b.
To determine:
The genotype of a person having a normal
Introduction:
The set of the alleles in DNA that carries the information for the expression of a trait in an individual is known as its genotype. For example, genotype ‘TT’ expresses the tallness in plants.
c.
To determine:
The total number of different alleles of a β-globin gene which can be carried by five children with the same mother and father.
Introduction:
An allele is an alternate type of a gene. Humans are known as diploid organisms because they have two alleles present on each genetic locus. Each allele is inherited from each parent.
Want to see the full answer?
Check out a sample textbook solutionChapter 3 Solutions
Genetics: From Genes to Genomes, 5th edition
- The following scenario can be seen on Ch 29 Clinical case study on Heredity (27-year-old with normal pregnancy): Mrs. Rodriguez’ blood type is type O, and her husband’s is type A. She is currently pregnant and she would like to know what type of blood her baby will have. For discussion 7 please answer the following questions: What are the genotype and phenotype of Mrs. Rodriguez? What are the genotype and phenotype of Mr. Rodriguez, given that Mr. Rodriguez’s mother has O blood type and his father has A blood type? (use Punnett Square on your worksheet to find out the genotype of Mr. Rodriquez) What is the probability that Mrs. Rodriguez’s baby will have O blood type? A? B? AB? (use Punnett Square as your worksheet) Type O =______% Type A = _____ % Type B =______% Type AB =______%arrow_forward2. STATEMENT: A woman and man both do not have sickle-cell anemia, but both had one parent who had sickle cell. Sickle-cell is an autosomal (somatic) recessive trait. a) What is the genotype for the woman, man and each of their parents? b) This couple unexpectedly is going to have their first child. i. What's the probability that their child will have not have sickle cell like the couple? ii. What's the probability that the child will have sickle cell like one the grandparents?arrow_forwardA research team interested in mapping human genes discovered a new restriction length polymorphism (RFLP). a. First, they test the RFLP in a family with the pedigree below. The individuals colored blue are affected by hemophelia, a blood clotting disease. Dad Mom daughter1 daughter2 son1 son1 On what chromosome is the RFLP found? Explain your answer. b. Next, they genotyped (determined the RFLP polymorphism, type 1 or type 2) of daughterl's family with the results shown below: husband daughter1 %3D Are the RFLP and the hemophilia gene linked? Explain your reasoning.arrow_forward
- A genetic variant of the HBB gene results in sickle cell anemia, a disorder than primarily affects people of Sub-Saharan African descent, including many black Americans. Sickle cell anemia is named after the shape of the red blood cells in individuals with this disorder. The diseased genetic variant in the HBB gene results in a malformed hemoglobin protein, which is responsible for the shape of the red blood cell. Patients diagnosed with this disorder often exhibit a variety of symptoms, such as episodes of pain, swelling of hands and feet, delayed growth, and vision problems amongst others. The malformed hemoglobin protein is an example of the relationship between genes and traits at the: molecular level. population level. cellular level. organism level.arrow_forwardComplete a new Punnett square below, for a woman who is a carrier for sickle cell, who is married to a man who has sickle cell. What are the possible genotypes that you can identify, what is the ratio of phenotypes that are possible, and what is the chance that any of the offspring are affected by sickle cell anemia?arrow_forwardBACKGROUND: Sickle cell disease is caused by a change in the gene for hemoglobin, which is the oxygen-carrying protein in red blood cells. Individuals who are homozygous for the sickle cell trait often cannot endure exercise. Individuals who are heterozygous for the trait can have sickle cell attacks under extreme conditions. Normal individuals (genotype: Hbnorm Hbnorm ) have only normal hemoglobin. Homozygous sickle cell individuals (genotype: Hbsc Hbsc ) 'have only sickle cell hemoglobin. Heterozygous individuals (genotype: Hbnorm Hbsc ) have both normal and sickle cell hemoglobin. terry Smith collapsed while running a race for his track team. A doctor said he had a sickle cell attack. Genetic tests were run on several family members. The test results are shown below. An X indicates that form of hemoglobin in red blood cells. PROBLEM: How can you determine the genotypes of people in a family? Subject Normal Hemoglobin Sickle Cell Hemoglobin Jerry Jerry's brother Jerry's younger…arrow_forward
- Consider a woman whose brother has hemophilia A but whose parents are healthy. What is the chance that she has inherited the hemophilia allele? What is the chance that the woman will conceive a son with hemophilia?arrow_forward3. D. A. B. C. 10. Familial hypercholesterolemia is the most common genetic cause of heart disease. It is caused by a dominant factor (C). The recessive factor (c) produces a protein that processes cholesterol normally and leads to a normal risk for heart disease. Answer the following questions about the inheritance of this disease. What is the phenotype of a woman whose genotype is Cc? What is the genotype of a man who has hypercholesterolemia but whose mother did not have the disease? If a man who is heterozygous for the disease marries a woman who is heterozygous for the disease, what is the chance that any child of theirs will inherit the disease? If a man who is homozygous dominant marries a woman who is homozygous recessive, what would you predict for the the genotypes and phenotypes of their children? If the first 2 children from the marriage described in D above have the disease, what is the chance that a third child would be normal? Explain your answer. 41arrow_forwardA child has a blood type of “B positive”. This child is known to be a heterozygote at the ABO blood type gene and also a heterozygote at the Rh blood type gene. Select all of the choices below that show possible parents of this child.a) Genotypes IA IA X IA IAb) Genotypes IA IA X IA i c) Genotypes IA i X IA id) Genotypes IA IA X IA IBe) Genotypes IA IA X IB if) Genotypes IA IA X i ig) Genotypes IA i X i ih) Genotypes IA i X IB ii) Genotypes IB IB X IB IBj) Genotypes IB IB X IB ik) Genotypes IB IB X IA il) Genotypes IB IB X i im) Genotypes IB i X IB in) Genotypes IB i X i io) Genotypes IB IB X IA IBp) Genotypes IA IA X IB IBq) Genotypes IA IB X IA IBr) Genotypes IA IB X IA is) Genotypes IA IB X IB it) Genotypes IA IB X i iu) Genotypes i i X i iv) Genotypes + + X + +w) Genotypes + + X + -x) Genotypes + + X - -y) Genotypes + - X + -z) Genotypes - - X + -a1) Genotypes - - X - -arrow_forward
- Given the information regarding sickle cell anemia, if two carriers were to have children, what would be the genotypes and phenotypes of their children? Would any of the children show symptoms of the disease?arrow_forwardA normal woman, whose father was a hemophiliac, marries a normal man. Determine the genotype of the woman and the man. Determine the possible genotypes of their children. What percent of male and female children would be hemophiliacs? What percent normal? Would any be carriers?arrow_forwardIn humans, hemophilia is a sex-linked trait. Females can be normal, carriers, or have the disease. Males will either have the disease or not (but they won’t ever be carriers). X H X H = female, non-hemophilic X H X h = female, carrier X h X h = female, hemophilia X H Y = male, non-hemophilic X h Y= male, hemophiliac a.) Show the cross of a man who has hemophilia with a woman who is a carrier. What is the probability that their children will have the disease? b.) A woman who is a carrier marries a non-hemophilic man. Show the cross. What is the probability that their children will have hemophilia? What sex will a child in the family with hemophilia be? c.) A woman who has hemophilia marries a non-hemophilic man. How many of their children will have hemophilia, and what is their sex?arrow_forward
- Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning