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Cervical Cancer Incidence in HPV-Positive Women
A persistent infection with one of about 10 strains of genital HPV (human papillomavirus) is the main risk factor for cervical cancer. The virus spreads easily by sexual contact, but vaccines that prevent infection have been available since 2006. The vaccines consist of viral proteins that self-assemble into virus-like particles. The particles are not infectious (they contain no viral DNA), but their component proteins trigger an immune response that can prevent HPV infection and the cervical cancer it causes.
In 2003, Michelle Khan and her coworkers published results of their 10-year study correlating HPV status with cervical cancer incidence in women (FIGURE 37.23). All 20,514 participants were free of cervical cancer when the study began.
FIGURE 37.23 Cumulative incidence rate of cervical cancer correlated with HPV status.
● HPV16 positive
○ HPV16 negative and HPV18 positive
▾ All other cancer-causing HPV types combined
▿ No cancer-causing HPV types was detected.
In which group would women infected with both HPV16 and HPVI8 fall?
To explain: The group in which the women infected with both HPV16 and HPV18 belong.
Concept introduction: Human papillomavirus (HPV) is a common virus that infects almost everyone at one or the other point in life. There are different strains for this virus and they are identified with a number. HPV16 and HPV18 increase the risk of cervical, vaginal, and vulvar cancer in women and also pellicle cancer in men. These strains can also cause anal cancer and throat cancer in both men and women
Refer to Fig. 37.23 “Cumulative incidence rate of cervical cancer correlated with HPV status” in the textbook. The category in which the females infected with both HPV16 and HPV18 strains belong to is best represented by the line showing the i...
Chapter 37 Solutions
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