Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 5, Problem 39P
A cross was performed between one haploid strain of yeast with the genotype a f g and another haploid strain with the genotype α f+ g+ (a and α are mating types). The resulting diploid was sporulated, and a random sample of 101 of the resulting haploid spores was analyzed. The following genotypic frequencies were seen:
| α f+ g+ | 31 |
| a f g | 29 |
| a f+ g+ | 14 |
| α f g | 13 |
| a f+ g | 6 |
| α f g+ | 6 |
| a f+ g+ | 1 |
| α f g | 1 |
| a. | Map the loci involved in the cross. |
| b. | Assuming all three genes are on the same chromosome arm, is it possible that a particular ascus could contain an α f g spore but not an a f g spore? If so, draw a meiosis that could generate such an ascus. |
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One yeast strain carries the alleles lys+ and arg+, whereas another strain has lys-3 and arg-2. The two strains were crossed toeach other, and an ascus obtained from this cross has four spores with the following genotypes: lys+ arg+, lys+ arg-2, lys-3arg+, and lys-3 arg 2. This ascus has
a. a parental ditype.b. a tetratype.c. a nonparental ditype.d. either a tetratype or a nonparental ditype.
The alleles his-5 and lys-1, found in yeast, result in cells that require histidine and lysine for growth, respectively. A cross was made between two haploid yeast strains that are his-5 lys-1 and his+ lys+. 973 tetrads were analyzed, with the following pattern:
7 tetrads with 2 his-5 lys+ spores and 2 his+ lys-1 spores
603 tetrads with 2 his-5 lys-1 spores and 2 his+ lys+ spores
363 tetrads with 1 his-5 lys-1 spore, 1 his-5 lys+ spore, 1 his+ lys-1 spores, and 1 his+ lys+ spore
Compute the map distance between these two genes using the method that considered double crossovers and the one that does not. Show your work. Which give the higher value? Why?
What is the frequency of single crossovers between these genes? Explain.
Based on the frequency of single-crossovers, how many double crossovers would one expect? Is positive interference occurring?
Three autosomal recessive mutations in yeast, all producing the same phenotype (m1, m2, and m3), are subjected to complementation analysis. Of the results shown below, which, if any, are alleles of one another? Predict the results of the cross that is not shown—that is, m2 * m3. Cross 1: m1 * m24 F1: all wild-type progeny Cross 2: m1 * m34 F1: all mutant progeny
Chapter 5 Solutions
Genetics: From Genes to Genomes
Ch. 5 - Choose the phrase from the right column that best...Ch. 5 - a. A Drosophila male from a true-breeding stock...Ch. 5 - Prob. 3PCh. 5 - The Punnett square in Fig. 5.4 shows how Mendels...Ch. 5 - In mice, the dominant allele Gs of the X-linked...Ch. 5 - In Drosophila, males from a true-breeding stock...Ch. 5 - If the a and b loci are 20 m.u. apart in humans...Ch. 5 - CCDD and ccdd individuals were crossed to each...Ch. 5 - In mice, the autosomal locus coding for the...Ch. 5 - In a particular human family, John and his mother...
Ch. 5 - Albino rabbits lacking pigment are homozygous for...Ch. 5 - In corn, the allele A allows the deposition of...Ch. 5 - If the a and b loci are 40 cM apart and an AA BB...Ch. 5 - Write the number of different kinds of phenotypes,...Ch. 5 - A DNA variant has been found linked to a rare...Ch. 5 - Figure 5.7a shows chromosomes during prophase of...Ch. 5 - Figure 5.7b shows bivalents in mouse primary...Ch. 5 - Cinnabar eyes cn and reduced bristles rd are...Ch. 5 - In Drosophila, the autosomal recessive dp allele...Ch. 5 - From a series of two-point crosses, the following...Ch. 5 - Map distances were determined for four different...Ch. 5 - In the tubular flowers of foxgloves, wild-type...Ch. 5 - In Drosophila, the recessive allele mb of one gene...Ch. 5 - A snapdragon with pink petals, black anthers, and...Ch. 5 - In Drosophila, three autosomal genes have the...Ch. 5 - Drosophila females heterozygous for each of three...Ch. 5 - Male Drosophila expressing the autosomal recessive...Ch. 5 - a. In Drosophila, crosses between F1 heterozygotes...Ch. 5 - A true-breeding strain of Virginia tobacco has...Ch. 5 - Prob. 30PCh. 5 - The following list of four Drosophila mutations...Ch. 5 - Do the data that Mendel obtained fit his...Ch. 5 - Two genes control color in corn snakes as follows:...Ch. 5 - A mouse from a true-breeding population with...Ch. 5 - Neurospora of genotype a c are crossed with...Ch. 5 - A cross was performed between one haploid strain...Ch. 5 - Prob. 40PCh. 5 - Prob. 41PCh. 5 - Indicate the percentage of tetrads that would have...Ch. 5 - Prob. 43PCh. 5 - This problem leads you through the derivation of a...Ch. 5 - a. In ordered tetrad analysis, what is the maximum...Ch. 5 - Prob. 46PCh. 5 - A single yeast cell placed on a solid agar will...Ch. 5 - Figure 5.29 shows mitotic recombination leading to...Ch. 5 - A diploid strain of yeast has a wild-type...Ch. 5 - In Drosophila, the yellow y gene is near the...Ch. 5 - Neurofibromas are tumors of the skin that can...Ch. 5 - Two important methods for understanding the...
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