Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 5, Problem 19P
In Drosophila, the autosomal recessive dp allele of the dumpy gene produces short, curved wings, while the autosomal recessive allele bw of the brown gene causes brown eyes. In a testcross using females heterozygous for both of these genes, the following results were obtained: wild-type wings, wild-type eyes 178 wild-type wings, brown eyes 185 dumpy wings, wild-type eyes 172 dumpy wings, brown eyes 181
In a testcross using males heterozygous for both of these genes, a different set of results was obtained: wild-type wings, wild-type eyes 247 dumpy wings, brown eyes 242
| a. | What can you conclude from the first testcross? |
| b. | What can you conclude from the second testcross? |
| c. | How can you reconcile the data shown in parts (a) and (b)? Can you exploit the difference between these two sets of data to devise a general test for synteny in Drosophila? |
| d. | The genetic distance between dumpy and brown is 91.5 m.u. How could this value be measured? |
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In Drosophila, the following genes and mutations are known:
Wing size – recessive allele for tiny wings – t; dominant allele for normal wings – T
Eye shape – recessive allele for narrow eyes – d; dominant allele for normal (oval) eyes – D
Eye color – recessive allele for white eyes – r; dominant allele for normal (red) eyes – R
The following cross is performed and the offspring analyzed – TtDdRr X Ttddrr. Give the probabilities for generating the following offspring
a. Flies with at least two recessive traits - Write your answer as a reduced fraction - e.g. 1/8
b. A trihybrid cross is now performed and the offspring analyzed. What is the probability of getting abnormal flies except for the eye shape which will be normal - Write your answer as a reduced fraction - e.g. 1/8
In Drosophila, a cross was made between a yellow-bodied male with vestigial wings and a wild-type (WT) female(brown body and normal wings). The F1 generation consisted of WT males and WT females. The F1 males and females were crossed, and the F2 progeny consisted of 16 yellow males with vestigial wings, 48 yellow males with WT wings, 15 brown males with vestigial wings, 49 WT males, 31 brown females with vestigial wings, and 97 WT females. Based on these results, explain the inheritance of the two genes (i.e. autosomal or sex-linked, dominant or recessive).
In Drosophila, white eyes (w) are recessive to red eyes (w+) at one locus and black body (b) is recessive to gray body (b+). A homozygous white eyes, gray bodied female is crossed with a homozygous red eyes, black bodied male to produce the F1 progeny. The F1 progeny are testcrossed and produce the following progeny:
White eyes, black body: 212
White eyes, gray body: 288
Red eyes, black body: 308
Red eyes, gray body: 192
Does the evidence indicate that w and b loci are linked? Explain why or why not?
If they are linked, what is the map distance between the two loci? If they are not linked, what is the map distance between the two loci? If they are linked, are the allels in the F1 in coupling or repulsion? How do you know?
Draw the genotypes of all individuals described in the problem (original parents, F1, testcross, and F2 progeny) using the appropriate notation.
Chapter 5 Solutions
Genetics: From Genes to Genomes
Ch. 5 - Choose the phrase from the right column that best...Ch. 5 - a. A Drosophila male from a true-breeding stock...Ch. 5 - Prob. 3PCh. 5 - The Punnett square in Fig. 5.4 shows how Mendels...Ch. 5 - In mice, the dominant allele Gs of the X-linked...Ch. 5 - In Drosophila, males from a true-breeding stock...Ch. 5 - If the a and b loci are 20 m.u. apart in humans...Ch. 5 - CCDD and ccdd individuals were crossed to each...Ch. 5 - In mice, the autosomal locus coding for the...Ch. 5 - In a particular human family, John and his mother...
Ch. 5 - Albino rabbits lacking pigment are homozygous for...Ch. 5 - In corn, the allele A allows the deposition of...Ch. 5 - If the a and b loci are 40 cM apart and an AA BB...Ch. 5 - Write the number of different kinds of phenotypes,...Ch. 5 - A DNA variant has been found linked to a rare...Ch. 5 - Figure 5.7a shows chromosomes during prophase of...Ch. 5 - Figure 5.7b shows bivalents in mouse primary...Ch. 5 - Cinnabar eyes cn and reduced bristles rd are...Ch. 5 - In Drosophila, the autosomal recessive dp allele...Ch. 5 - From a series of two-point crosses, the following...Ch. 5 - Map distances were determined for four different...Ch. 5 - In the tubular flowers of foxgloves, wild-type...Ch. 5 - In Drosophila, the recessive allele mb of one gene...Ch. 5 - A snapdragon with pink petals, black anthers, and...Ch. 5 - In Drosophila, three autosomal genes have the...Ch. 5 - Drosophila females heterozygous for each of three...Ch. 5 - Male Drosophila expressing the autosomal recessive...Ch. 5 - a. In Drosophila, crosses between F1 heterozygotes...Ch. 5 - A true-breeding strain of Virginia tobacco has...Ch. 5 - Prob. 30PCh. 5 - The following list of four Drosophila mutations...Ch. 5 - Do the data that Mendel obtained fit his...Ch. 5 - Two genes control color in corn snakes as follows:...Ch. 5 - A mouse from a true-breeding population with...Ch. 5 - Neurospora of genotype a c are crossed with...Ch. 5 - A cross was performed between one haploid strain...Ch. 5 - Prob. 40PCh. 5 - Prob. 41PCh. 5 - Indicate the percentage of tetrads that would have...Ch. 5 - Prob. 43PCh. 5 - This problem leads you through the derivation of a...Ch. 5 - a. In ordered tetrad analysis, what is the maximum...Ch. 5 - Prob. 46PCh. 5 - A single yeast cell placed on a solid agar will...Ch. 5 - Figure 5.29 shows mitotic recombination leading to...Ch. 5 - A diploid strain of yeast has a wild-type...Ch. 5 - In Drosophila, the yellow y gene is near the...Ch. 5 - Neurofibromas are tumors of the skin that can...Ch. 5 - Two important methods for understanding the...
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