Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 5, Problem 9P
In mice, the autosomal locus coding for the ß-globin chain of hemoglobin is 1 m.u. from the albino locus.Assume for the moment that the same is true in humans. The disease sickle-cell anemia is the result of homozygosity for a particular mutation in the ß-globin gene.
| a. | A son is born to an albino man and a woman with sickle-cell anemia. What kinds of gametes will the son form, and in what proportions? |
| b. | A daughter is born to a normal man and a woman who has both albinism and sickle-cell anemia. What kinds of gametes will the daughter form, and in what proportions? |
| c. | If the son in part (a) grows up and marries the daughter in part (b), what is the probability that a child of theirs will be an albino with sickle-cell anemia? |
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In mice, the autosomal locus coding for the β-globinchain of hemoglobin is 1 m.u. from the albino locus. Assume for the moment that the same is true in humans. The disease sickle-cell anemia is the result ofhomozygosity for a particular mutation in theβ-globin gene.a. A son is born to an albino man and a woman withsickle-cell anemia. What kinds of gametes will theson form, and in what proportions?b. A daughter is born to a normal man and a womanwho has both albinism and sickle-cell anemia.What kinds of gametes will the daughter form,and in what proportions?c. If the son in part (a) grows up and marries thedaughter in part (b), what is the probability that achild of theirs will be an albino with sickle-cellanemia?
Shown below is a pedigree for Phenylketonuria (PKU), an autosomal recessive metabolic disorder. The characteristic feature of PKU is severe mental retardation
A) What is the probability that individual II-1 is heterozygous for this gene?
B) What is the probability that individual III-4 is heterozygous for this gene?
C) If individuals III-3 and III-4 were to marry, what is the probability that their child would express PKU?
A rare blinding disease that has a relation to dengenerative factors is partially penetrant. In the following pedigrees for two families, the affected symptomatic individuals (black circles and squares) have been diagnosed with this disease due to the mutation in mitochondrial DNA m.14484T>C.
If III.4 is homoplasmic for m.14484T>C in hair, blood, urine and other tissues examined. What will occur with IV.7 then?
Chapter 5 Solutions
Genetics: From Genes to Genomes
Ch. 5 - Choose the phrase from the right column that best...Ch. 5 - a. A Drosophila male from a true-breeding stock...Ch. 5 - Prob. 3PCh. 5 - The Punnett square in Fig. 5.4 shows how Mendels...Ch. 5 - In mice, the dominant allele Gs of the X-linked...Ch. 5 - In Drosophila, males from a true-breeding stock...Ch. 5 - If the a and b loci are 20 m.u. apart in humans...Ch. 5 - CCDD and ccdd individuals were crossed to each...Ch. 5 - In mice, the autosomal locus coding for the...Ch. 5 - In a particular human family, John and his mother...
Ch. 5 - Albino rabbits lacking pigment are homozygous for...Ch. 5 - In corn, the allele A allows the deposition of...Ch. 5 - If the a and b loci are 40 cM apart and an AA BB...Ch. 5 - Write the number of different kinds of phenotypes,...Ch. 5 - A DNA variant has been found linked to a rare...Ch. 5 - Figure 5.7a shows chromosomes during prophase of...Ch. 5 - Figure 5.7b shows bivalents in mouse primary...Ch. 5 - Cinnabar eyes cn and reduced bristles rd are...Ch. 5 - In Drosophila, the autosomal recessive dp allele...Ch. 5 - From a series of two-point crosses, the following...Ch. 5 - Map distances were determined for four different...Ch. 5 - In the tubular flowers of foxgloves, wild-type...Ch. 5 - In Drosophila, the recessive allele mb of one gene...Ch. 5 - A snapdragon with pink petals, black anthers, and...Ch. 5 - In Drosophila, three autosomal genes have the...Ch. 5 - Drosophila females heterozygous for each of three...Ch. 5 - Male Drosophila expressing the autosomal recessive...Ch. 5 - a. In Drosophila, crosses between F1 heterozygotes...Ch. 5 - A true-breeding strain of Virginia tobacco has...Ch. 5 - Prob. 30PCh. 5 - The following list of four Drosophila mutations...Ch. 5 - Do the data that Mendel obtained fit his...Ch. 5 - Two genes control color in corn snakes as follows:...Ch. 5 - A mouse from a true-breeding population with...Ch. 5 - Neurospora of genotype a c are crossed with...Ch. 5 - A cross was performed between one haploid strain...Ch. 5 - Prob. 40PCh. 5 - Prob. 41PCh. 5 - Indicate the percentage of tetrads that would have...Ch. 5 - Prob. 43PCh. 5 - This problem leads you through the derivation of a...Ch. 5 - a. In ordered tetrad analysis, what is the maximum...Ch. 5 - Prob. 46PCh. 5 - A single yeast cell placed on a solid agar will...Ch. 5 - Figure 5.29 shows mitotic recombination leading to...Ch. 5 - A diploid strain of yeast has a wild-type...Ch. 5 - In Drosophila, the yellow y gene is near the...Ch. 5 - Neurofibromas are tumors of the skin that can...Ch. 5 - Two important methods for understanding the...
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