Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
expand_more
expand_more
format_list_bulleted
Concept explainers
Textbook Question
Chapter 5, Problem 42P
Indicate the percentage of tetrads that would have 0, 1, 2, 3, or 4 viable spores after Saccharomyces cerevisiae a / α diploids of the following genotypes are sporulated:
a. | A true-breeding wild-type strain (with no mutations in any gene essential for viability). |
b. | A strain heterozygous for a null (completely inactivating) mutation in a single essential gene. |
For the remaining parts of this problem, consider crosses between yeast strains of the form
|
|
c. | a and b are unlinked, and both are 0 m.u. from the centromere. |
d. | a and b are unlinked; a is 0 m.u. from the centromere, while b is 10 m.u. from the centromere. |
e. | a and b are 0 m.u. apart. |
f. | a and b are 10 m.u. apart. Assume all crossovers between a and b are SCOs (single crossovers). |
g. | In part (f), if a four-strand DCO (double crossover) occurred between a and b, how many of the spores in the resulting tetrad would be viable at high temperature? |
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Neurospora of genotype a + c are crossed withNeurospora of genotype + b +. (Here, + is shorthandfor the wild-type allele.) The following tetrads areobtained (note that the genotype of the four sporepairs in an ascus are listed, rather than listing alleight spores):a + c a b c + + c + b c a b + a + ca + c a b c a + c a b c a b + a b c+ b + + + + + b + + + + + + c + + ++ b + + + + a b + a + + + + c + b +137 141 26 25 2 3a. In how many cells has meiosis occurred to yieldthese data?b. Give the best genetic map to explain these results.Indicate all relevant genetic distances, both betweengenes and between each gene and the centromere.c. Diagram a meiosis that could give rise to oneof the three tetrads in the class at the far right inthe list
Three autosomal recessive mutations in yeast, all producing the same phenotype (m1, m2, and m3), are subjected to complementation analysis. Of the results shown below, which, if any, are alleles of one another? Predict the results of the cross that is not shown—that is, m2 * m3. Cross 1: m1 * m24 F1: all wild-type progeny Cross 2: m1 * m34 F1: all mutant progeny
A heterozygous diploid yeast Aa Bb went through meiosis. What percentage of the haploid spores will have recombinant combinations of alleles?
What if genes A and B are unlinked? Explain
What is genes A and B are linked? Explain
Chapter 5 Solutions
Genetics: From Genes to Genomes
Ch. 5 - Choose the phrase from the right column that best...Ch. 5 - a. A Drosophila male from a true-breeding stock...Ch. 5 - Prob. 3PCh. 5 - The Punnett square in Fig. 5.4 shows how Mendels...Ch. 5 - In mice, the dominant allele Gs of the X-linked...Ch. 5 - In Drosophila, males from a true-breeding stock...Ch. 5 - If the a and b loci are 20 m.u. apart in humans...Ch. 5 - CCDD and ccdd individuals were crossed to each...Ch. 5 - In mice, the autosomal locus coding for the...Ch. 5 - In a particular human family, John and his mother...
Ch. 5 - Albino rabbits lacking pigment are homozygous for...Ch. 5 - In corn, the allele A allows the deposition of...Ch. 5 - If the a and b loci are 40 cM apart and an AA BB...Ch. 5 - Write the number of different kinds of phenotypes,...Ch. 5 - A DNA variant has been found linked to a rare...Ch. 5 - Figure 5.7a shows chromosomes during prophase of...Ch. 5 - Figure 5.7b shows bivalents in mouse primary...Ch. 5 - Cinnabar eyes cn and reduced bristles rd are...Ch. 5 - In Drosophila, the autosomal recessive dp allele...Ch. 5 - From a series of two-point crosses, the following...Ch. 5 - Map distances were determined for four different...Ch. 5 - In the tubular flowers of foxgloves, wild-type...Ch. 5 - In Drosophila, the recessive allele mb of one gene...Ch. 5 - A snapdragon with pink petals, black anthers, and...Ch. 5 - In Drosophila, three autosomal genes have the...Ch. 5 - Drosophila females heterozygous for each of three...Ch. 5 - Male Drosophila expressing the autosomal recessive...Ch. 5 - a. In Drosophila, crosses between F1 heterozygotes...Ch. 5 - A true-breeding strain of Virginia tobacco has...Ch. 5 - Prob. 30PCh. 5 - The following list of four Drosophila mutations...Ch. 5 - Do the data that Mendel obtained fit his...Ch. 5 - Two genes control color in corn snakes as follows:...Ch. 5 - A mouse from a true-breeding population with...Ch. 5 - Neurospora of genotype a c are crossed with...Ch. 5 - A cross was performed between one haploid strain...Ch. 5 - Prob. 40PCh. 5 - Prob. 41PCh. 5 - Indicate the percentage of tetrads that would have...Ch. 5 - Prob. 43PCh. 5 - This problem leads you through the derivation of a...Ch. 5 - a. In ordered tetrad analysis, what is the maximum...Ch. 5 - Prob. 46PCh. 5 - A single yeast cell placed on a solid agar will...Ch. 5 - Figure 5.29 shows mitotic recombination leading to...Ch. 5 - A diploid strain of yeast has a wild-type...Ch. 5 - In Drosophila, the yellow y gene is near the...Ch. 5 - Neurofibromas are tumors of the skin that can...Ch. 5 - Two important methods for understanding the...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- To understand the genetic basis of locomotion in the diploid nematode Caenorhabditis elegans, recessive mutations were obtained, all making the worm “wiggle” ineffectually instead of moving with its usual smooth gliding motion. These mutations presumably affect the nervous or muscle systems. Twelve homozygous mutants were intercrossed, and the F1 hybrids were examined to see if they wiggled. The results were as follows, where a plus sign means that the F1 hybrid was wild type (gliding) and “w” means that the hybrid wiggled.a. Explain what this experiment was designed to test. b. Use this reasoning to assign genotypes to all 12 mutants. c. Explain why the phenotype of the F1 hybrids between mutants 1 and 2 differed from that of the hybrids between mutants 1 and 5arrow_forwardIn barley, a self-fertilizing species that can be cross-fertilized, two true-breeding strains withvirescent leaves occur. In strain A, the trait is caused by a cytoplasmic gene while in strainB it is by a recessive chromosomal gene. Illustrate the crossing of each F1 in (a) to each of the paternal strains What phenotypes would you expect among theprogeny, and in what proportions in each of the following? Illustrate your crosses below,indicate and the female and male parent for each cross, and write the phenotype of allthe parents and offspring(s).arrow_forwardIn barley, a self-fertilizing species that can be crossed fertilized, two true-breeding strains with virescent leaves exist. In strain A, the trait is caused by a cytoplasmic gene. In strain B, it is caused by a recessive nuclear gene. What phenotypes would you expect among the progeny and in what proportions in each of the following: a cross between homozygous strain A and strain B reciprocal cross Self-fertilization of the F1 from a Self-fertilization of the F1 from barrow_forward
- A single yeast cell placed on a solid agar will dividemitotically to produce a colony of about 107cells. Ahaploid yeast cell that has a mutation in the ade2 genewill produce a red colony; an ade2+ colony will bewhite. Some of the colonies formed from diploidyeast cells with a genotype of ade2+/ ade2− willcontain sectors of red within a white colony.a. How would you explain these sectors?b. Although the white colonies are roughly the samesize, the red sectors within some of the whitecolonies vary markedly in size. Why? Do youexpect the majority of the red sectors to be relativelylarge or relatively small?arrow_forwardThe life cycle of the haploid fungus Ascobolus is similar tothat of Neurospora. A mutational treatment producedtwo mutant strains, 1 and 2, both of which when crossedwith wild type gave unordered tetrads, all of the followingtype (fawn is a light brown color; normally, crosses produce all black ascospores):spore pair 1 black spore pair 3 fawnspore pair 2 black spore pair 4 fawna. What does this result show? Explain.The two mutant strains were crossed. Most of the unordered tetrads were of the following type:spore pair 1 fawn spore pair 3 fawnspore pair 2 fawn spore pair 4 fawnb. What does this result suggest? Explain.When large numbers of unordered tetrads were screenedunder the microscope, some rare ones that containedblack spores were found. Four cases are shown here:Case A Case B Case C Case Dspore pair 1 black black black blackspore pair 2 black fawn black abortspore pair 3 fawn fawn abort fawnspore pair 4 fawn fawn abort fawn(Note: Ascospores with extra genetic material…arrow_forward. Imagine that you have done a cross between twostrains of yeast, one of which has the genotype A B Cand the other a b c, where the letters refer to threerather closely linked genes in the order given. Youexamine many tetrads resulting from this cross, andyou find two that do not contain the expected two Band two b spores. In tetrad I, the spores are A B C, AB C, a B c, and a b c. In tetrad II, the spores are A BC, A b c, a b C, and a b c. How have these unusualtetrads arisen?arrow_forward
- At the molecular level (with regard to loss-of-function alleles), explain why the ttvv homozygote has an ovate seed capsule.arrow_forwardPlease label the tetrad type in the table as PD (parental ditype), NPD (non parental ditype) or T (tetratype) and answer the following questions a) Are the genes linked? Please explain SPECIFICALLY how you can distinguish between linked and unlinked genes in this instance. b) If the two genes are linked, calculate the % recombination between ser and thr. Show the formula used, as well as all of your calculations. c) Draw a single map illustrating the arrangement of the two genes on the chromosome with respect to each other and to the centromere of the chromosome. Make sure to map ALL three distancesarrow_forwardIn the haploid yeast Saccharomyces cerevisiae, the twomating types are known as MATa and MATα. You cross apurple (ad-) strain of mating type a and a white (ad+)strain of mating type α. If ad- and ad+ are alleles of onegene, and a and α are alleles of an independently inherited gene on a separate chromosome pair, what progenydo you expect to obtain? In what proportions?arrow_forward
- Wild-type strains of the haploid fungus Neurospora canmake their own tryptophan. An abnormal allele td renders the fungus incapable of making its own tryptophan.An individual of genotype td grows only when its medium supplies tryptophan. The allele su assorts independently of td; its only known effect is to suppress the tdphenotype. Therefore, strains carrying both td and su donot require tryptophan for growth.a. If a td ; su strain is crossed with a genotypically wildtype strain, what genotypes are expected in the progenyand in what proportions?b. What will be the ratio of tryptophan-dependent totryptophan-independent progeny in the cross of part a?arrow_forwardOne yeast strain carries the alleles lys+ and arg+, whereas another strain has lys-3 and arg-2. The two strains were crossed toeach other, and an ascus obtained from this cross has four spores with the following genotypes: lys+ arg+, lys+ arg-2, lys-3arg+, and lys-3 arg 2. This ascus has a. a parental ditype.b. a tetratype.c. a nonparental ditype.d. either a tetratype or a nonparental ditype.arrow_forwardIn an autotetraploid organism, the gene controlling coat color is very near the centromere of the chromosome carrying it. The allele Y for the yellow coat is dominant to y for blue coat. A homozygous yellow autotetraploid strain is crossed with a homozygous blue autotetraploid strain. What types and proportions of gametes would the F1 be expected to produce if the Y locus were 40 or more map units from the centromere? Derive the expected F2 phenotypic ratio. Please explain coherently. Thank you!arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY